Kuby immunology ch Study guides, Class notes & Summaries

Kuby Immunology Exam 1 (Ch. 1-5) – Q’s And A’s

Kuby Immunology (Ch. 5-7) Exam Questions All Solved Which of the following is NOT usually induced in response to TLR signaling? A. TNF-α B. IL-1 C. iNOS D. IL-6 E. IL-4 - Answer - E. IL-4 Where would you MOST likely find a TLR that recognizes RNA? A. On the cell surface B. In the endosome/lysosome C. In the nucleus D. In the mitochondria E. In the endoplasmic reticulum - Answer - B. In endosome/lysosome Activation of dendritic cells with TLR4 or TLR5 results in the production...

Kuby immunology - Ch. 8-11 Exam Correct Answers New Update Distinction between BCR and TCR - Answer - BCR can recognize free floating antigen; TCR sees processed antigen on an MHC molecule Major function of MHC 1 - Answer - Present peptide antigen to CD8+ (Tc) Major function of MHC 2 - Answer - Present processed peptide antigen to CD4+ (Th) Histocompatibility - Answer - A state of mutual tolerance between tissues that allows them to be grafted effectively Polymorphism - Answer - T...

Kuby Immunology CH 5 Exam Correct Answers Kinases - Answer - Add phosphate groups Response time of Innate Immune system - Answer - Minutes/Hours Response time of Adaptive Immune system - Answer - Days Specificity of Innate System - Answer - Specific for molecules and molecular patterns associated with pathogens and molecules produced by dead/damaged cells Specificity of Adaptive System - Answer - Highly specific; discriminates b/w even minor differences in molecular structure of m...

Define "immunity" - ️️The state of being resistant to reinfection with a pathogen What happens to a pathogen as it becomes attenuated? - ️️It has weakened virulence Which of the following is the BEST example of herd immunity? - ️️A child infected with measles travels from Germany to the USA. Several babies contract the disease, but the outbreak is largely contained due to vaccinations. Which of the following diseases does NOT currently have an effective vaccine? A) Chic...

What is immunity? - ANSWER A state of protection from infectious diseases What is the immune system? - ANSWER The cells and molecules that are responsible for immunity What is an immune response? - ANSWER The coordinated response to the introduction of foreign substances.

Define stem cells. - ANSWER Ability to regenerate or "self-renew" Ability to differentiate into all diverse cell types Describe hematopoiesis. - ANSWER Formation and development of blood cells What cell type gives rise to all blood cells? - ANSWER Hematopoietic stem cell (HSC) Why is the study of hematopoiesis difficult? - ANSWER Because there is roughly 1 HSC per 50,000 cells in bone marrow, HSC function decreases with age, "Lin" markers found on mature cells Undifferentiated cells l...

What is immunity? - ️️A state of protection from infectious diseases What is the immune system? - ️️The cells and molecules that are responsible for immunity What is an immune response? - ️️The coordinated response to the introduction of foreign substances. Explain how Edward Jenner and Louis Pasteur made advancements in the development of immunity. - ️️Jenner targeted smallpox. He inoculated an 8 year old boy with the mild disease cowpox. After he introduced smallpox an...

Tolerance - ANSWER A stage of immunologic unresponsiveness to particular antigens or sets of anitgens; Typically, an organism is unresponsive or tolerant to self antigens Sequential Epitopes - ANSWER Two or more antigenic determinants formed by a single sequence of amino acids. Nonsequential Epitopes - ANSWER Epitopes that are far apart in the primary sequence of the polypetide chain, but close together in the teritary structure of the molecules.

These are specialized sites in the gut and other mucosal tissues that coordinate the encounter of antigen with antigen-specific lymphocytes and their development into effector and memory cells. ex. spleen, lymph nodes - ANSWER secondary lymphoid organs These organs (thymus and bone marrow) regulate the development of immune cells from immature precursors. - ANSWER primary lymphoid organs It gives rise to all functionally specialized, mature blood cells (red blood cells, granulocytes, macro...