CBNS 120 final exam questions &
answers 2024/2025
Facilitation is a form of "short term synaptic plasticity" that leads to: - ANSWERSprogressive increase in
EPP amplitude
Why does facilitation occur? - ANSWERSResidual calcium in the nerve terminal
What does synaptic depression result from? - ANSWERSDepletion of the readily releasable store of
synaptic vesicles
What does synaptic depression lead to? - ANSWERSReduction in EPP amplitude
What is short term increase in EPP amplitude? - ANSWERSFacilitation
What is short term decrease in EPP amplitude? - ANSWERSSynaptic depression
What is long term increase in EPSP amplitude? - ANSWERSLTP
What is long term decrease in EPSP amplitude? - ANSWERSLTD
What is essential for induction of LTP1: - ANSWERSNMDA receptors and ryanodine receptors
What does the induction of LTP3 require? - ANSWERSphosphorylation of CREB and voltage gated calcium
channels
synaptic depression may result from: - ANSWERSca/calmodulin binding to the IM and CBD motifs of the
calcium channel
, Induction of hippocampal LTD involved: - ANSWERS-activation of phosphatases
-prolonged low level increase of calcium in the postsynaptic cell
-reduction of postsynaptic AMPA receptor density
What are the critical components of cerebellar LTD? - ANSWERSmetabotropic glutamate receptors
In Aplysia, long term sensitisation: - ANSWERS-involves new gene expression
-depends on activation of CREB
-involves formation of new synapses
Inhibitors of CAMKII: - ANSWERSblock LTP1
Induction of hippocampal LTP1 and LTP2 depends on: - ANSWERSincreased density of postsynaptic AMPA
receptors
Silent synapses have: - ANSWERSCAMKII and NMDA receptors
(AMPA not prevalent mostly)
Common features of long term sensitisation in Aplysia and long-term potentiation in mammals: -
ANSWERS-new synapse formation
-increased kinase activity
-phosphorylation of CREB
NMDA receptors: - ANSWERS-are subject to voltage-dependent block by Mg 2+ ions
-exist at silent synapses in the absence of AMPA receptors
Short term sensitisation in Aplysia results from: - ANSWERS-activation of PKA
-phosphorylation of voltage-dependent K channels
-spike broadening (increased spike duration)
answers 2024/2025
Facilitation is a form of "short term synaptic plasticity" that leads to: - ANSWERSprogressive increase in
EPP amplitude
Why does facilitation occur? - ANSWERSResidual calcium in the nerve terminal
What does synaptic depression result from? - ANSWERSDepletion of the readily releasable store of
synaptic vesicles
What does synaptic depression lead to? - ANSWERSReduction in EPP amplitude
What is short term increase in EPP amplitude? - ANSWERSFacilitation
What is short term decrease in EPP amplitude? - ANSWERSSynaptic depression
What is long term increase in EPSP amplitude? - ANSWERSLTP
What is long term decrease in EPSP amplitude? - ANSWERSLTD
What is essential for induction of LTP1: - ANSWERSNMDA receptors and ryanodine receptors
What does the induction of LTP3 require? - ANSWERSphosphorylation of CREB and voltage gated calcium
channels
synaptic depression may result from: - ANSWERSca/calmodulin binding to the IM and CBD motifs of the
calcium channel
, Induction of hippocampal LTD involved: - ANSWERS-activation of phosphatases
-prolonged low level increase of calcium in the postsynaptic cell
-reduction of postsynaptic AMPA receptor density
What are the critical components of cerebellar LTD? - ANSWERSmetabotropic glutamate receptors
In Aplysia, long term sensitisation: - ANSWERS-involves new gene expression
-depends on activation of CREB
-involves formation of new synapses
Inhibitors of CAMKII: - ANSWERSblock LTP1
Induction of hippocampal LTP1 and LTP2 depends on: - ANSWERSincreased density of postsynaptic AMPA
receptors
Silent synapses have: - ANSWERSCAMKII and NMDA receptors
(AMPA not prevalent mostly)
Common features of long term sensitisation in Aplysia and long-term potentiation in mammals: -
ANSWERS-new synapse formation
-increased kinase activity
-phosphorylation of CREB
NMDA receptors: - ANSWERS-are subject to voltage-dependent block by Mg 2+ ions
-exist at silent synapses in the absence of AMPA receptors
Short term sensitisation in Aplysia results from: - ANSWERS-activation of PKA
-phosphorylation of voltage-dependent K channels
-spike broadening (increased spike duration)
