Genetics Brooker summary chapter 14 - Gene regulation in bacteria
34 views 1 purchase
Course
Genetics
Institution
Vrije Universiteit Amsterdam (VU)
Book
ISE Genetics
These summaries (in English and provided with many supporting figures from the book) will help you to obtain a great grade for the course 'Genetics' in the first year of Biomedical Sciences at the VU. With learning al my summaries and lecture notes (see my other documents), I finished this course w...
Summary ISE Genetics Analysis and Principles - Genetics Part 2!!
Chapter 1, overview of genetics
Complete Test Bank Genetics Analysis and Principles 7th Edition Brooker Questions & Answers with rationales (Chapter 1-29)
All for this textbook (60)
Written for
Vrije Universiteit Amsterdam (VU)
Bachelor Biomedical Sciences
Genetics
All documents for this subject (37)
Seller
Follow
simonezweers19
Reviews received
Content preview
Genetics summary – VU BMS 2020/2021
Simone Zweers
Reference: Brooker, Genetics: Analysis and prinicples, 7th edition
Chapter 14: Gene regulation in bacteria
1
, Genetics summary – VU BMS 2020/2021
Simone Zweers
Reference: Brooker, Genetics: Analysis and prinicples, 7th edition
- Gene regulation is the phenomenon in which the level of gene
expression can vary under different conditions
- Constitutive genes are unregulated genes always expression
encode proteins that are continuously needed for the survival of
the bacterium
- Common processes regulated at the genetic level:
o Metabolism – some proteins function in the metabolism of
small molecules for example enzymes that are only
required when the sugars are present in the environment of
the bacterium
o Response to environmental stress – certain proteins
help a bacterium to survive an environmental stress
o Cell division – some proteins are needed for cell division
- Common points where regulation of gene expression occurs in
bacteria:
14.1: Overview of transcriptional regulation
- Influencing the rate of transcription is the most common way to
regulate bacterial gene expression
- Regulatory proteins that bind to DNA and affect the transcription rate
o Repressor – binds to DNA, inhibits transcription
o Activator – binds to DNA, increases the rate of transcription
o Negative control – transcriptional regulation by a repressor
o Positive control – transcriptional regulation by an activator
- Small effector molecules also play a critical role in transcriptional regulation do not
bind to DNA binds to a repressor/activator conformational change, influences the
binding of the protein to the DNA
- The regulatory proteins have two binding sites: where it bind to DNA and to the effector
o Inducer – increases the rate of transcription can bind to repressor to prevent it
from binding to the DNA, can
bind to activator to cause it to
bind to DNA inducible
genes are regulated this way
o Corepressor – binds to a
repressor, causing the protein
to bind to DNA
o Inhibitor – bind to activator,
prevents it from binding to
DNA
Repressible genes
are regulated by
corepressors/inhibitors
2
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller simonezweers19. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $3.77. You're not tied to anything after your purchase.
