Genetics Brooker summary chapter 15 - Gene regulation in eukaryotes
36 views 1 purchase
Course
Genetics
Institution
Vrije Universiteit Amsterdam (VU)
Book
ISE Genetics
These summaries (in English and provided with many supporting figures from the book) will help you to obtain a great grade for the course 'Genetics' in the first year of Biomedical Sciences at the VU. With learning al my summaries and lecture notes (see my other documents), I finished this course w...
Summary ISE Genetics Analysis and Principles - Genetics Part 2!!
Chapter 1, overview of genetics
Complete Test Bank Genetics Analysis and Principles 7th Edition Brooker Questions & Answers with rationales (Chapter 1-29)
All for this textbook (60)
Written for
Vrije Universiteit Amsterdam (VU)
Bachelor Biomedical Sciences
Genetics
All documents for this subject (37)
Seller
Follow
simonezweers19
Reviews received
Content preview
Genetics summary – VU BMS 2020/2021
Simone Zweers
Reference: Brooker, Genetics: Analysis and prinicples, 7th edition
Chapter 15: Gene regulation in eukaryotes: transcriptional and translational
regulation
1
, Genetics summary – VU BMS 2020/2021
Simone Zweers
Reference: Brooker, Genetics: Analysis and prinicples, 7th edition
- Gene regulation = the phenomenon in which the level of gene expression is controlled
so that genes can be expressed at high or low levels
15.1: regulatory transcription factors
- Transcription factors are proteins that influence the ability of RNA polymerase to
transcribe DNA into RNA
- General transcription factors: required for the binding of RNA polymerase to the core
promoter and progression to the elongation stage
- Regulatory transcription factors: regulate the rate of transcription of target genes
influence the ability of RNA polymerase to begin transcription of a particular gene
recognize cis-acting elements near the promoter regulatory sequences, control
elements, regulatory elements
o Activators bind to enhancers
o Repressors bind to silencers
- Combinatorial control = most eukaryotic genes are regulated by many factors
- Transcription: factors that commonly contribute to combinatorial control:
o Activator proteins stimulate the ability of RNA pol. to
initiate transcription
o Repressor proteins inhibit initiation of transcription
o Small effector molecules, protein-protein interactions
or covalent modifications may modulate the function of
activators/repressors
o Regulatory proteins alter the composition/arrangement
of nucleosomes in the vicinity of a promoter
o DNA methylation can inhibit transcription preventing
the binding of an activator
o Formation of heterochromatin may inhibit gene
expression
2
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller simonezweers19. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $3.74. You're not tied to anything after your purchase.