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Genetics Brooker summary chapter 25 - Genetic basis of cancer $3.74
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Genetics Brooker summary chapter 25 - Genetic basis of cancer

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These summaries (in English and provided with many supporting figures from the book) will help you to obtain a great grade for the course 'Genetics' in the first year of Biomedical Sciences at the VU. With learning al my summaries and lecture notes (see my other documents), I finished this course w...

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  • Chapter 25 - genetic basis of cancer
  • March 1, 2021
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  • 2020/2021
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Genetics summary – VU BMS 2020/2021
Simone Zweers
Reference: Brooker, Genetics: Analysis and prinicples, 7th edition

Chapter 25: Genetic basis of cancer




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, Genetics summary – VU BMS 2020/2021
Simone Zweers
Reference: Brooker, Genetics: Analysis and prinicples, 7th edition


- Cancer is a disease characterized by uncontrolled cell division
- It is a genetic disease at the cellular level
- More than 100 kinds of human cancers are known
o These are classified according to the type of cell that has become
cancerous
o 10% as inherited trait
- Carcinogens = environmental agents that increase the likelihood of
developing cancer

25.1: Overview of cancer
- Most originate from a single cell, cancerous growth can be considered to be
clonal
- At the cellular and genetic level, cancer is usually a multistep process
o Begins with a precancerous genetic change  benign growth =
goedaardig, followed by additional genetic changes, progresses to
cancerous cell growth
- When cells have become cancerous, the growth is described as malignant
 cells are invasive (can invade healthy tissue) and metastatic (can
migrate to other parts of the body)
- Two affects of genetic changes that lead to cancer
o Oncogene = mutant gene that is overexpressed and contributes to
cancerous growth
o Tumor-suppressor gene = gene that prevents cancers. A loss-of-
function mutation in a tumor-suppressor gene can allow cancerous
growth to occur

25.2: Oncogenes
- Proto-oncogene = a normal, nonmutated gene that has the potential to become an
oncogene
o To become an oncogene, it incurs a mutation that causes its expression to be
abnormally high (gain of function)
- Three possible effects of fain of function mutation that produces an oncogene
o The amount of the encoded protein is greatly increased
o A change occurs in the structure of the encoded protein that causes it to be
overly active
o The encoded protein is expressed in a cell type where it is not normally
expressed

Oncogenes have gain-of-function mutations that may affect proteins involved in cell division
pathways
- Cell in G1 may accumulate molecular changes that cause it to advance through the rest
of the cell cycle
- Growth factors are signaling molecules that coordinate cell division
- Epidermal growth factor EGE, secreted from endocrine, stimulates epidermal cells to
divide
- Binds to receptor  activation of intracellular signaling pathway  changes gene
transcription, activated. The proteins promote progression through the cell cycle  cell
stimulated to divide
- Oncogenes commonly encode proteins that function in cell-signaling pathways related to
cell division


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