Other
NSG 6005 Midterm Exam Study Guide / NSG6005 Midterm Exam Study Guide (Latest, 2020): South University
- Course
- Institution
NSG 6005 Midterm Exam Study Guide / NSG6005 Midterm Exam Study Guide (Latest, 2020): South University
[Show more]
Seller
Follow
waldenquiz
Reviews received
Content preview
1NSG 6005 Advanced Pharmacology Midterm—Study Guide
, 2
NSG 6005 Advanced Pharmacology Midterm—Study Guide
There will be 75 questions on the Midterm. Most will be multiple choice. There are a
couple True/False and 5 matching questions. I suggest you review your PowerPoints and
Textbook Assignments. I hope this study guide is helpful
Make sure you know the following topics very well.
• When a medication is listed below, make sure you know all about it and how
to apply it to different patient situations: What disease process it is used
for?, how does it work?, when should it not be used?, adverse effects,
pros/cons, interactions, patient education factors (should it be taken w/ food?
At bedtime?), tapering, preliminary and post treatment labs, black box
warnings/CI, etc.
• If a disease process is mentioned below—know how to diagnose and
recommended treatment guidelines.
1) General principles of pharmacokinetics and dynamics?
PHARMACOKINETICS- What the body does to the drug”
Absorption –Entry of drug to the blood stream. Usually depends on passive diffusion of drug
through cell membranes.
• Absorption depends on: blood flow at site, drugs lipid soluability (>lipic,
>soluabililty that directly penetrate the memebrane), local PH and drug ionization
(non-ionized absorb better), pharmaceutical processing (coatings and additives.
• Blood brain barrier: allow lipid soluable only. May pump out any drug that it sees
as foreign, hard to treat CNS infections.
, 3
• Placenta: allows lipid drugs so does not protect from lipid soluable drugs, which
is why pregnant women are limited to drugs. Know gestation age.
•
Distribution
: fat ratio changes may alter distribution, especially a people age.
• Fat soluable drugs may be accumulated: weight loss will release these drugs.
• Water soluable drugs are affected by dehydration
Biotransformation (Metabolism) : Drugs become more hydrophilic (water soluable) for
excretion.
• Also referred to as the P450 system or cytochrome P450 system. (a group
of enzymes in the liver identified for their ability to breakdown drugs.)
• Hepatic“First Pass Effect” (parenteral (IV or IM) meds bypass this
enzymatic effect)
• breaks PO meds down to some degree, some are protected with coating
but they don’t always work
• Metabolites
Usually less active, less toxic, easier
• to excrete
• Prodrugs - inactive in form given but metabolized to active drug (ex:
enalapril)
• Liver function determined by liver enzymes
, 4
• Failing liver produces fewer enzymes, drugs available longer: caution
•
• Excretion:Process by which medications are eliminated from the body unchanged or as
metabolites
• Kidneys are main organ of excretion
• If poor renal function, drug may accumulate, may
wish to prescribe less of drug
• Also eliminated via respiration, breast milk, defecation. Tears, sweat, saliva not as
significant.
• START LOW AND GO SLOW!!!!
PHARMOCODYNAMICS- “effect of drug on the body”
Receptors: Drugs must bind to for effect o Help a process happen: agonist
oBlock a process from happening: antagonist o Know that:
• All drugs have an effect
• A drug’s ability to cause a response is called its efficacy
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller waldenquiz. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $15.49. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
76462 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy study notes for 14 years now