Class notes
Lecture Notes
- Course
- Institution
Lecture notes of 7 pages for the course Metabolic Pathways at QMUL
[Show more]
Seller
Follow
fatima-attia
Reviews received
Content preview
Amino acid breakdownLearning objective:
1. Linkage between aa breakdown and the citric acid cycle
2. How breakdown of AA leads to creation of another AA
3. The process of methionine breakdown
4. Diseases that can result from the process of enzyme dysfunction
5. The process involved in phenylalanine/ tyrosine catabolism
6. The diseases (PKU) and the treatment there of in phenylalanine catabolism
Background information
Nitrogen to urea
- Where does the carbon skeleton go?
Degraded into citric acid cycle components or their precursors
AA breakdown creates new AA
LO1. LINKAGE OF AA BREAKDOWN INTO CITRIC ACID CYCLE
Glucogenic/ ketogenic AA
20 AA with different breakdown pathways
Glucogenic AA
- AA that can be converted to glucose through glycogenesis ( formation of glycogen from sugar)
- Breakdown to glucose precursors
Pyruvate
Α-ketoglutarate
Succinyl-Co-A
Fumerate
Oxaloacetate
- 13 AA
Ketogenic AA
- Come from fatty acid breakdown
- AA that can be degraded directly into acetyl-coA, which is the precursor of ketone bodies.
- Break down to ketone bodies precursor
Acetyl-CoA (acetoacetyl-CoA)
- 2 AA (leucine & lysine)
Glucogenic & ketogenic AA
- IIe
- Thr
- Phe
- Tyr
- Trp
AA are heavily
lined to the citric
acid cycle
, Specifics- covered briefly
AA that make
1. Pyruvate
- Alanine
- Cysteine
- Glycine
- Serine
- Threonine
- Include tryptophan, which makes alanine
2. Oxaloacetate
- Asparagine
- Aspartate
- Asparagine makes aspartate
3. Α-ketoglutamarate
- Arginine
- Glutamate
- Glutamine
- Histadine All to glutamate then to α-ketoglutamate
- Proline
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller fatima-attia. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $3.89. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
66475 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy study notes for 14 years now