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Lecture notes of 24 pages for the course Transmission Genetics at QMUL
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By: betulalm • 3 year ago
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DNA RepairLearning objectives:
1. Types of DNA repair
2. Molecular mechanisms involved in repairing DNA
DNA damage: how bad is it?
Damage to DNA occurs continuously
In humans approx. 500,000 modifications occur per cell per day
It is minimised by several different DNA repair systems (>130 repair gene)
How does DNA damage occur?
Endogenous Agents
- Formed inside the cell by normal metabolic pathways
Exogenous Agents
- Come from the surrounding environment
,Consequence of DNA damage
DNA damage & repair mechanisms
Which response/type of repair generally depends on the type/nature of the damage
, DNA repair mechanisms
Direct reversal
Excision repair (3 types)
Recmbinatorial repair (2 types)
Translation repair
Direct repair
Direct repair mechanism are rare
Involves the direct reversal or simple removal of the damage
Repair of photodimers
Repair of alkylated bases
Direct repair- photodimers
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