100% satisfaction guarantee Immediately available after payment Both online and in PDF No strings attached
logo-home
Lecture Notes $3.88   Add to cart

Class notes

Lecture Notes

1 review
 21 views  0 purchase
  • Course
  • Institution

Lecture notes of 10 pages for the course Membrane and cellular Biochemistry at QMUL

Preview 2 out of 10  pages

  • March 6, 2021
  • 10
  • 2020/2021
  • Class notes
  • Guy
  • All classes

1  review

review-writer-avatar

By: betulalm • 3 year ago

avatar-seller
Membrane transport II
Learning objectives:

1. Describe the different mechanisms of regulatory control of ion channels
2. Explain the structural basis of voltage gating, using eukaryotic K V channels as an example
3. Describe the differences between the three conformational states of a
4. eukaryotic voltage-gated K+ channel
5. Compare and contrast the basic mechanisms of K + channels and the glucose transporters
6. Explain the mechanism of Na+/K+ ATPase
7. Define the term ‘secondary transport’ and explain how the driving force for this type of transport is generated

Voltage-Gated K+ Channels from Eukaryotes

• Are called KV channels
• Four identical or homologous subunits, each subunit containing six transmembrane a-helices
• Two functionally distinct domains:
- Pore domain (helices S5, S6 and P segment homologous to helices M1, M2 and P segment in KcsA)
- Voltage sensing domain consisting of helices S1 to S4

, Three-Dimensional Structure of the KV1.2 Channel Purified from Rat Brain (activation gate open)




Gating mechanism of K+ Channels from Eukaryotes

 Amino acid sequence of S4 helix shows a number of positively charged amino acid residues

The benefits of buying summaries with Stuvia:

Guaranteed quality through customer reviews

Guaranteed quality through customer reviews

Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.

Quick and easy check-out

Quick and easy check-out

You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.

Focus on what matters

Focus on what matters

Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!

Frequently asked questions

What do I get when I buy this document?

You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.

Satisfaction guarantee: how does it work?

Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.

Who am I buying these notes from?

Stuvia is a marketplace, so you are not buying this document from us, but from seller fatima-attia. Stuvia facilitates payment to the seller.

Will I be stuck with a subscription?

No, you only buy these notes for $3.88. You're not tied to anything after your purchase.

Can Stuvia be trusted?

4.6 stars on Google & Trustpilot (+1000 reviews)

66475 documents were sold in the last 30 days

Founded in 2010, the go-to place to buy study notes for 14 years now

Start selling
$3.88
  • (1)
  Add to cart