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Lecture notes of 13 pages for the course Cell Biology and developmental genetics at QMUL
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By: betulalm • 3 year ago
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Revision lectureCell communicate to maintain or establish cell polarity
With the cellular environment:
- Growth factor
- Growth factor receptor
- ECM
- Integrins
With the surrounding cells:
- Cell-cell junction (cadherins)
These communications all influence the ‘’inside’’ of the cell:
- Signalling pathways
- Cytoskeleton (actin, microtubules, IF)
And lead to cell responses:
- Maintain apical-basal polarity
- Migration
Growth factor and growth factor receptors
, Receptor tyrosine kinase (RTK)
Paracrine signalling
Proto-oncogene
There are different ways for RTK or GF receptor to become oncogenic.
- One of the ways is autocrine signalling, overexpression, gene amplification, receptor mutation.
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