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Lecture notes of 14 pages for the course Cell Biology and developmental genetics at QMUL
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By: betulalm • 3 year ago
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Lecture 22Cell communication to maintain or establish cell polarity
Cell polarity can be either basal/ apical or rear to front
Cells communicate with the cellular environment:
- growth factor
- growth factor receptors
- ECM
- Integrins
Cells communicate with the surrounding cells:
- cell-cell junctions (cadherins)
cadherin is not a receptor for a substrate
Cadherin undergoes homophillic binding (= 1 cadherin binds to another in the neighbour cell)
these communications all influence the ‘’inside’’ of the cell:
- signalling pathways (switched on)
- Change in cytoskeleton (actin, microtubules, IF)
and leads to cell responses:
- maintain apical-basal polarity
- migration
Growth factor and growth factor receptors
GF trigger different cell responses
- Proliferation
- Survival
- Migration
Immediate response
- Do not require gene transcription
Delayed response
- Require gene transcription
, Receptor tyrosine kinase (RTK)
GF bind to respective GF receptor
Most GF receptors are RTK but not all
- RTK is a GF receptor but a GF receptor is not always an RTK
There is an RTK family and all have a kinase domain (in red)
- The kinase domain is enzymatic and phosphorylates some docking sites downstream the kinase domain on the
receptor
paracrine signalling
proto-oncogene
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