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Lecture notes of 3 pages for the course Cell Biology and developmental genetics at QMUL
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Cells and tissues: neural subtype diversityLearning objectives:
1. Spatial and temporal mechanisms determine the identity of individual stem cells and their progeny
Neurogenesis can be subdivided into four processes- last week lecture
Neurogenesis
- The growth and developmet of nervous tissue
Two main processes contribute to the generation of neural diversity
There are 2 main processes that contribute to the generation of neural diversity:
1. Spatial patterning
– looking at whole neuroectroderm, there are different genes expressed in different regions. Because of this
differential gene expression mentioned in the first lecture, these cells will differentiate
Temporal regulation of formation
In vertebrates: in some cases the identity of a neuron can be influences
(a) as it migrates to its final position
(b) after innervation of its target tissue
Regional subdivison of ventral neuroectoderm
During the formation of neuroectoderm, genes are expressed in the neural ectoderm
Each neuroblast expresses a different subset of segment polarity and dorso-ventral patterning genes
During the formation of neuroectoderm, genes are expressed in the neural ectoderm
Some of those genes are segment polarity genes
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