Class notes
Human Papilloma Virus Notes
- Course
- Institution
Lecture notes of 4 pages for the course Medical Microbiology II at Gulf Medical University (Q&S based)
[Show more]
Seller
Follow
LinJawish
Content preview
L10 Human Papilloma VirusExplain the morphology of papova viruses
They are non-enveloped viruses that have an icosahedral, nucleocapsid, supercoiled DS circular DNA
Figure 1: Icosahedral structure
What are the two types of papova virus?
a. Papillomaviruses
b. Polyomaviruses
Describe papillomaviruses:
They are viruses that induce hyperplastic epithelial lesions in their host. They exhibit tissue and cell
specificity, hence why they only infect epithelial surfaces and mucosal membranes.
There are 100 types of HPV that have been recognized, and 73 genotypes identified. Each genotype is
associated with a specific clinical entity.
Like they family that they originate from, HPV ae also unenveloped “naked” DNA viruses.
Not grown on culture.
Replication takes place in nucleus
The virus is produced from skin warts while complete virions ae not released from malignant lesions.
What does the ds-genome of HPV encode for?
- 7 early regulatory polypeptides (E1-E7)
- 2 late structural proteins (L1-L2)
Viral DNA replication and expression of late proteins are restricted to differentiating cells.
What is the role of the 7 regulatory proteins?
E1 & E2 are DNA binding proteins involved in regulating viral transcription and replication
E6 & E7 change the activity of cell regulatory proteins that govern the admission into, as well as the
speed, cell division cycle, and differentiation pathways.
What are the types of lesions that lead to malignancies?
a. Lesions with high risk of progression into malignancy
Cervical Carcinoma
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller LinJawish. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $7.49. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
75323 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy study notes for 14 years now