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Measles Virus Notes
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Lecture notes study book Medical Microbiology of Michael R. Barer, Will L. Irving, Nelun Perera (Chapter 44) - ISBN: 9780702072000 (Q&S based)
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L-7 MeaslesWhat is measles?
A highly infectious acute viral disease of childhood.
What are the general signs of measles?
- Fever
- Respiratory symptoms
- Maculopapular rash
Provide details of measles virus.
it is a morbillivirus
- A genus of viruses known to case skin rash, amongst other things
It is enveloped, and has a ss negative-sense RNA genome
- Doesn’t encode mRNA
what does the measles genome encode?
- Nucleoprotein
- Phosphoprotein
- Matrix
- Fusion fusion of virus and host cell membranes, as well as viral penetration and hemolysis
- Hemagglutinin binds to cellular receptors CD46 & CD150
viral membrane glycoproteins that are involved in viral entry, they are also the main target of
virus-neutralizing antibodies.
- Polymerase
Demonstrate the outline of Pathogenesis and provide an insight on it
Humans only natural host
Respiratory Lymphoid Primary Secondary
Tract Tissue Viremia Viremia
(Blood) (Organs)
Virus enters Further Fever willl virus spreads to
human body multiplication start epitherlial
and multiply occurs surfaces (skin,
locally RT, conjunctiva)
where it will
undergo focal
replication.
Can measles replicate within cells? is its Significant?
Yes. Measles replicates within certain lymphocytes, which aids in its distribution throughout the body.
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