Samenvatting H1 t/m H5 + H7, H8 van Handboek Proefdierkunde
18 views 0 purchase
Course
Cursus tot Biotechnicus
Institution
Cursus Tot Biotechnicus
Book
Handboek proefdierkunde
Het betreft een samenvatting van H1 t/m H5 + H7, H8 van het Handboek proefdierkunde. Hierin worden onder andere huisvesting, gebruik, standaardisatie, microbiologische kwaliteit, barrière systemen, biologie en zoötechniek besproken.
, 1.2 Geschiedenis van het proefdiergebruik....................................................................................6
1.3 Proefdiergebruik en onderzoeksdoeleinden.............................................................................7
1.4 De ‘’THREE Rs’’ Van Russell en Bruch........................................................................................8
1.5 Onderwijs in de proefdierkunde...............................................................................................8
Hoofdstuk 2: Wettelijke aspecten van dierproeven...........................................................................9
2.1 Internationale inbedding..........................................................................................................9
2.2 Definitie van een dierproef.......................................................................................................9
2.3 Het vergunningenstelsel...........................................................................................................9
2.4 Alternatieven............................................................................................................................9
2.5 Deskundigheid........................................................................................................................10
2.6 Huisvestiging, verzorging en verwerving.................................................................................10
2.7 De proefdierdeskundige.........................................................................................................10
2.8 Registratie...............................................................................................................................10
2.9 De centrale commissie dierproeven (CCD).............................................................................10
2.10 Dierexperimentencommissie (DEC)......................................................................................10
2.11 Toezicht VWA.......................................................................................................................11
2.12 Primaten...............................................................................................................................11
2.13 Codes of practice..................................................................................................................11
2.14 Andere wetgeving.................................................................................................................11
2.15 Maatschappelijke discussie en verenigingen........................................................................11
Hoofdstuk 3: Biologie en zoötechniek..............................................................................................12
3.1 Kleine zoogdieren...................................................................................................................12
3.2 Grote zoogdieren....................................................................................................................19
3.3 Vogels.....................................................................................................................................22
3.5 Amfibieën...............................................................................................................................25
3.6 Vissen......................................................................................................................................25
Hoofdstuk 4: Gedrag, stress en welzijn.............................................................................................27
4.1 Basale mechanismen..............................................................................................................27
4.2 Wisselwerking tussen dier en omgeving.................................................................................28
4.3 Wisselwerking tussen omgeving en fysiologie........................................................................30
4.4 Functionele betekenis van fysiologische stressresponsen......................................................30
4.5 Stoornissen in de fysiologie....................................................................................................30
4.6 Welzijn....................................................................................................................................31
Hoofdstuk 5: Standaardisatie van dierproeven................................................................................32
5.1 Waarom standaardisatie?.......................................................................................................32
5.2 Standaardisatie en extrapolatie/ generalisatie.......................................................................32
, 5.3 Replicaties...............................................................................................................................32
5.4 Variatie binnen en tussen groepen.........................................................................................32
5.5 Dierproeven volgens het kwaliteitssysteem Good Laboratory Practice (GLP)........................33
5.6 Origineel protocol...................................................................................................................33
5.7 Geplande en onvoorziene afwijkingen van het protocol........................................................34
5.8 Beperkingen van standaardisatie............................................................................................34
Hoofdstuk 7: Genetische standaardisatie.........................................................................................35
7.1 Genetische uniformiteit..........................................................................................................35
7.2 Transgene dieren (transgenese en targeted gene transfer)...................................................37
7.3 Genetische variatie.................................................................................................................42
7.4 Genetische kwaliteitsbewaking..............................................................................................43
7.5 Genetische verwantschap van inteeltstammen......................................................................43
7.6 Cryopreservatie......................................................................................................................43
Hoofdstuk 8: Microbiologische standaardisatie...............................................................................44
8.1 Redenen voor microbiologisch kwaliteitsbeheerder bij proefdieren......................................44
8.2 Besmettingsbronnen en besmettingsroutes...........................................................................44
8.3 Microbiologische kwaliteiten..................................................................................................45
8.4 Barrière systemen...................................................................................................................46
8.5 Kwaliteitscontrole...................................................................................................................47
8.6 Vaccinaties en therapieën.......................................................................................................48
Hoofdstuk 1: Inleiding........................................................................................................................4
1.1 Proefdierkunde en dierproeven...............................................................................................4
1.2 Geschiedenis van het proefdiergebruik....................................................................................4
1.3 Proefdiergebruik en onderzoeksdoeleinden............................................................................5
1.4 De ‘’THREE Rs’’ Van Russell en Bruch.......................................................................................6
1.5 Onderwijs in de proefdierkunde...............................................................................................6
Hoofdstuk 2: Wettelijke aspecten van dierproeven...........................................................................7
2.1 Internationale inbedding..........................................................................................................7
2.2 Definitie van een dierproef.......................................................................................................7
2.3 Het vergunningenstelsel...........................................................................................................7
2.4 Alternatieven............................................................................................................................7
2.5 Deskundigheid..........................................................................................................................8
2.6 Huisvestiging, verzorging en verwerving..................................................................................8
2.7 De proefdierdeskundige...........................................................................................................8
2.8 Registratie.................................................................................................................................8
2.9 De centrale commissie dierproeven (CCD)...............................................................................8
, 2.10 Dierexperimentencommissie (DEC)........................................................................................8
2.11 Toezicht VWA.........................................................................................................................9
2.12 Primaten.................................................................................................................................9
2.13 Codes of practice....................................................................................................................9
2.14 Andere wetgeving...................................................................................................................9
2.15 Maatschappelijke discussie en verenigingen..........................................................................9
Hoofdstuk 3: Biologie en zoötechniek..............................................................................................10
3.1 Kleine zoogdieren...................................................................................................................10
3.2 Grote zoogdieren....................................................................................................................17
3.3 Vogels.....................................................................................................................................20
3.5 Amfibieën...............................................................................................................................23
3.6 Vissen.....................................................................................................................................23
Hoofdstuk 4: Gedrag, stress en welzijn............................................................................................25
4.1 Basale mechanismen..............................................................................................................25
4.2 Wisselwerking tussen dier en omgeving.................................................................................26
4.3 Wisselwerking tussen omgeving en fysiologie........................................................................28
4.4 Functionele betekenis van fysiologische stressresponsen......................................................28
4.5 Stoornissen in de fysiologie....................................................................................................28
4.6 Welzijn....................................................................................................................................29
Hoofdstuk 5: Standaardisatie van dierproeven................................................................................30
5.1 Waarom standaardisatie?.......................................................................................................30
5.2 Standaardisatie en extrapolatie/ generalisatie.......................................................................30
5.3 Replicaties..............................................................................................................................30
5.4 Variatie binnen en tussen groepen.........................................................................................30
5.5 Dierproeven volgens het kwaliteitsysteem Good Laboratory Practice (GLP)..........................31
5.6 Origineel protocol...................................................................................................................31
5.7 Geplande en onvoorziene afwijkingen van het protocol........................................................32
5.8 Beperkingen van standaardisatie............................................................................................32
Hoofdstuk 7: Genetische standaardisatie.........................................................................................33
7.1 Genetische uniformiteit..........................................................................................................33
7.2 Transgene dieren (transgenese en targeted gene transfer)...................................................35
7.3 Genetische variatie.................................................................................................................37
7.4 Genetische kwaliteitsbewaking..............................................................................................38
7.5 Genetische verwantschap van inteeltstammen......................................................................38
7.6 Cryopreservatie......................................................................................................................38
Hoofdstuk 8: Microbiologische standaardisatie...............................................................................39
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller Niempje21. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $6.48. You're not tied to anything after your purchase.