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Samenvatting Farmacologie - diuretica $6.21   Add to cart

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Samenvatting Farmacologie - diuretica

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Hoofdstuk 8 samengevat van farmacologie

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  • Hoofdstuk 8
  • April 19, 2021
  • 3
  • 2020/2021
  • Summary
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HOOFDSTUK 8 : DIURETICA
 Stimuleren diuretica
 ook wel ‘vochtafdrijvers’ of ‘plaspillen’ genoemd
 Door een verhoogd vochtverlies neemt het bloedvolume af en hierdoor ook de vulling van het
hart en bloeddruk.

Indicatie:
 hoge bloeddruk
 water – en zoutopstapeling in het lichaam, bv. bij hartfalen, longoedeem, levercirrose, acuut
glaucoom…

doelwit:
 transportsystemen en ionkanalen ter hoogte van de nier

belangrijkste soorten diuretica:
 lisdiuretica
 thiaziden
 kaliumsparende diuretica

 effect lisdiuretica en thiaziden > effect kaliumsparende diuretica

a. lisdiuretica

 Snelle en krachtige diuretica
 Voornamelijk als snelle diurese gewenst is, bv. hartfalen, acuut glaucoom, acuut longoedeem,
nierfalen,…

Aangrijpingspunt:
 Na+/K+/2Cl- - co-transporter (in het opstijgende deel van Lis van Henle)
 Hier wordt normaal 25% van het natrium heropgenomen
 Verlies van natrium, kalium, calcium, magnesium en water

  Na+/K+/2Cl- - co-transporter
  dikke opstijgende deel van Lis van Henle
  verlies van natrium, chloor, kalium en water
  ook verlies calcium en magnesium

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