question 1 clinical manifestations of mild to moderate splenomegaly and hepatomegaly
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NR 507 (NR507)
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NR 507 WEEK 3 QUIZ (Advanced Pathophysiology)
Question 1
Clinical manifestations of mild to moderate splenomegaly and hepatomegaly,
bronze-colored skin, and cardiac dysrhythmias are indicative of which anemia?
Sideroblastic
Aplastic
You Answered
Pernicious
Iron deficiency
Mild to moderate enlargement of the spleen (splenomegaly) and liver
(hepatomegaly) occurs. Occasionally, abnormal skin pigmentation (bronze
colored) is seen. Heart rhythm disturbances, along with congestive heart failure,
are major life-threatening complications related to cardiac iron overload.
Question 2
What is the pathophysiologic process of aplastic anemia?
Autoimmune disease against hematopoiesis by activated immunoglobulins
Inherited genetic disorder with recessive X-linked transmission
Malignancy of the bone marrow in which unregulated proliferation of erythrocytes
crowd out other blood cells
Correct!
Autoimmune disease against hematopoiesis by activated cytotoxic T cells
Most cases of AA result from an autoimmune disease directed against
hematopoietic stem cells. Cytotoxic T cells (Tc cells) appear to be the main
culprits.
, Question 3
Pernicious anemia generally requires continued therapy lasting
6 to 8 weeks.
Correct!
the rest of one’s life.
until the iron level is normal.
8 to 12 months.
PA cannot be cured, so maintenance therapy is lifelong.
Question 4
Symptoms of polycythemia vera are mainly the result of
destruction of erythrocytes.
Correct!
increased blood viscosity.
neurologic involvement.
a decreased erythrocyte count.
As the disease progresses many of the symptoms are related to the increased blood
cellularity and viscosity.
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