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samenvatting epithelen
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Samenvatting o.b.v. het hoofdstuk epithelen in het boek functionele histologie en de cursus.
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Histologie: epithelenAlgemeen
Beschermen van onderliggende weefsel
o Bedekken lichaamsppervlak
o Lijnen lichaamsholgen en kanalen af
Regulatie van opname en afgifte van stoffen
Vormt klieren (klierepitheel)
Gespecialisserde epitheliale weefsels
Bestaan uit 1 of meer lagen van epitheelcellen
Cellen sluiten nauw aaneen
Zeer weinig extracellulaire matrix (LM: dicht opeengeplakte cellen, EM: nauwe spleten)
Cellen zijn verbonden met elkaar door intercellulaire verbindingen
Basaalmembraan = afgrenzing van onderliggende bindweefsellaag
Bevat GEEN bloedvaten
Bloedvoorziening
Bloedvaten dringen nooit binnen in epitheel weefsel
-> epitheel is dus afhankelijk van diffusie van zuurstof en VS van onderliggende weefsels
Epitheelcel
Cytoskelet van epitheelcel bestaat uit keratine
KERATINE
Keratine-eiwitten worden in alle epitheelcellen geproduceerd
Specifiek type keratine in specifieke epitheelcel
Kunnen keratine-filamenten vormen (invermediaire filamenten)
Belangrijk voor keratinisering en verhoorning
CELPOLARITEIT
=> epitheelcellen zijn gepolariseerd: apicale, basale, laterale domeinen zijn functioneel verschillend
Epitheel gesteund door onderliggend basaalmembraan
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