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Samenvatting CW (Cel tot Weefsel) Overzicht Celdood en Adaptatie $4.28
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Samenvatting CW (Cel tot Weefsel) Overzicht Celdood en Adaptatie

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Dit is een overzicht van celdood en adaptatie voor CW (Cel tot Weefsel) uit het eerste jaar van de studie Diergeneeskunde.

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  • May 15, 2021
  • 4
  • 2020/2021
  • Summary
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Overzicht Celdood en Adaptatie
Necrose
● Lelijke celdood → de cel ontploft
● Organellen van ontplofte cellen komen in het extracellulaire milieu en veroorzaken
een ontstekingsreactie
● Oorzaak: zuurstoftekort
○ Zuurstoftekort → ATP tekort
■ Vanwege metabolisme
○ ATP tekort → celzwelling
■ Na+/K+ pomp stopt met werken
■ Na+ hoopt op aan de binnenkant
en K+ aan de buitenkant
■ Water gaat de cel in door
osmose
○ Zwelling → slechte functionering
■ Hydropische degeneratie
● Verloop van necrose
1. Cellen zwellen op en de kern
condenseert
○ Pyknotische cel
2. De kern valt uit elkaar →
gefragmenteerde kern
○ Karyorrhectische cel
3. De cel ontploft → lysosomale
afbraak (karyolyse)
○ Karyolytische cel
● Soorten necrose
○ Coagulatie necrose
■ Weefselstructuur is intact
■ Weefsel is bleek
■ Lysosomale enzymen
inactief
○ Liquefactieve/lytische/colliquatie
necrose
■ Weefselstructuur
verloren
■ Lysosomale enzymen
zijn actief
● Calcificatie
○ Intercellulaire Ca2+ concentratie neemt toe
○ Extreme Ca2+ influctie → accumulatie → calcificatie

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