Samenvatting van het hoofdstuk 5 (deeltje cytologie) van het boek Cytologie en Histologie van Prof dr. Calders.
Het deeltje gaat over intracellulaire communicatie.
door activatie van G-proteïne sluiten of openen de kanalen meer
C: VERBONDEN MET G-PROTEÏNE
verbonden met enzyme
Hierbij worden dan de secundaire boodschappers geproduceerd die via een cascademechanisme de
kanaalactiviteit beïnvloeden.
Bij activatie van het adenylaatcyclase via Gs-proteïne vorming cyclisch adenosine monofosfaat uit
ATP activatie proteïnekinasen fysiologisch effect
parallel voor guanylaatcyclase (adenine= guanine)
Bij activatie van het fosfolipase C fosfatidylinositoldifosfaat (PIP2) gesplitst in diacylgycerol (DAG)
en inositoltrifosfaat (IP3) Calcium komt vrij uit ER bindt op specifieke bindingsproteïnen
fysiologisch effect
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