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Day 11
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Lecture 11:Chapter 5: Modelling genetic drift with coalescence theory
The coalescent process:
- So far: we have considered drift by looking forward. We considered the probability that two
alleles were identical.
- Another way is to look backwards in time and to consider the time scale.
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,Assumptions Wright-Fisher population model:
- Population size N is constant through time
- Each individual gets replaced every generation
- Next generation is drawn randomly from a large gamete pool
- Only genetic drift is manipulating the allele frequencies
, The coalescent process:
- Coalescence theory shows how the properties of samples of alleles from populations depend
on the genealogy connecting them.
- Two distinct processes:
o The formation of a genealogy for the alleles in a sample
o The imposition of mutations on the tree.
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