Fundamentals of Drug Discovery, Response and Mechanisms of Action
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Course
Fundamentals Of Pharmacology (4BBY1040)
Institution
Kings College London (KCL)
Includes detailed notes on the following lectures:
Lecture 1: What is Pharmacology? - (Ian McFadzean)
Lecture 2: Sources of drugs and their nature - (Ian McFadzean)
Lecture 3: Principles of drug action I - (Ian McFadzean)
Lecture 4: Principles of drug action II - (Ian McFadzean)
Lecture 5: M...
Differences between pharmacology, therapeutics, pharmacy and
toxicology
Pharmacology: science of drugs involved in the development and discovery of
new effective drugs, specifically through its interaction mechanisms.
Therapeutics: Medicinal use of drugs to relieve symptoms of disease. (not
all drugs = medicine)
Pharmacy: How medicines are formulated and dispensed for use as medicine.
Includes the law governing the medicinal use of drugs.
Toxicology: The branch of pharmacology that focusses on harmful effects of
chemicals or drugs
Definition and categorization of drugs
Chemical substance of know structure, other than a nutrient or a non-essential
dietary ingredient, which, when administered to a living organism produces a
biological effect.
Drugs are endogenous molecules that block or mimic the actions of endogenous
molecules by binding to molecular targets within the body
Grouped by: Mechanis
Therapeutic use Common Chemical Therapeutic Proprieta
m of
Mechanism of name name use ry name
action
action
4-[2-tert- Preferenti
Named by: butylamin al effect Bronchial
Salbutam
Chemical name o]-1- on beta 2 asthma Proventil
ol
Common name (hydryleth adrenergic symptoms
Proprietary name yl)-phenol receptors
1-
naphethle
Summarise the key n-1-yloxy-
mechanisms by which 3-(propan-
Sodium
drugs might produce Proprano 2-ol-
channel Anti-anxiety Inderal
their effects lol ylamine)
blockade
propan-2-
By interacting with: ol
Receptors for hydrochlor
neurotransmitters ide
or hormones
Enzymes
Ion channels
Carrier or transporter proteins
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