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Class notes BI644 Biology of Ageing (BI644) Week 1-3
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Class notes for BI644 Biology of Ageing Week 1-3
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BI644 – Biology of Ageing1.1 Introduction
To me studying ageing means studying life:
How organisms work throughout life
o Growth and development
o Different physiological systems
What changes or goes wrong with time.
o Mild changes/pathologies of ageing
o Age-related diseases
Understanding the underlying molecular biology.
o Signalling pathways/their individual components
Interactions or organisms with their environment
Course Structure
Week 13 Introduction
Week 14 Skills for Biogerontologists
Week 15 Critical Analysis of Lifespan Data (workshops)
Week 16 Genetics of Ageing Biology
Week 17 Nutritional Regulation of Ageing Biology
Week 18 Ageing and the microbiome
Week 19 -
Week 20 Diseases of Ageing
Week 21 Research Talk 1
Week 22 Research Talk 2
Week 23 Feedback and Revision
Integrate knowledge as you go
Understanding how the signalling pathways work is key for
developing therapies for ageing.
Assessments
Coursework (40%)
Critical Analysis of Lifespan data
This assessments has an associated 2hr workshop (week 15) designed to guide you through it. You
will be divided into 3 groups for this – prepare in advance.
Assessment proforma and marking criteria available on Moodle.
Examination (60%)
One compulsory data analysis section.
One essay section (choice of 3).
, BI644 – Biology of Ageing
Notes
Lifespan can be manipulated by making genetic or environmental changes to an organism. How can
we manipulate lifestyle:
Good diet
Keeping brain active
Healthy sleeping pattern
Exercise
Regeneration of stem cells
Inherited genetics
Vaccinations
Reduced alcohol intake
Reduced sugar intake
Genetic engineering
Hallmarks of Ageing
Overview of the Importance and Principles of Ageing Research
Ageing biology wasn’t important until the
beginning of the 20th Century. Until then
average lifespan was between 35-40 years.
Until the 20th Century scientists/biologists
focused on curing diseases.
Current ageing research works to improve the late-life health of humans, rather than trying to make
people live forever. As well as making people live
longer, they want people to be as healthy as they
can for as long as they can.
Some organisms, such as Hydra and sea
anemones don’t seem to age at all.
It is possible to alter lifespan and improve age-related health.
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