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Post-Exposure Prophylaxis

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A one-page summary Infection and Defence Notes on Post-Exposure Prophylaxis from a 4.00 GPA student. Notes are well-structured, easy to read, with tables and keyword colors. The details are summarized into short phrases in bullet points and fit into one page for spatial recall.

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  • June 12, 2021
  • 1
  • 2020/2021
  • Class notes
  • Mr. kriangkai
  • All classes
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Post-Exposure Prophylaxis
Infectious Diseases Regimen

Hepatitis B virus Vaccinated: none
Previous vaccinated (not complete): hep B immune globulin followed by vaccine booster
Not vaccinated: hep B immune globulin followed by vaccine series

Hepatitis C virus No prophylaxis

HIV Any injury/mucocutaneous exposure: within 72 hrs for 28 days → Tenofovir + one prophylaxis (choose)

Varicella zoster virus Vaccinated: none
Not vaccinated: 2 cases
1) Healthy: vaccine within 5 days of exposure
2) Pregnant, neonate, immunocompromised: varicella zoster immune globulin asap

Rabies Vaccinated:
1) Last vaccine more than 6 months: 2 dose of vaccine
2) Last vaccine less than 6 months: 1 dose of vaccine
Not vaccinated: immediate vaccine followed by rabies immune globulin (category III)

Measles Vaccinated: none
*droplets & airborne Not vaccinated:
1) Healthy: vaccine within 3 days of exposure
2) Pregnant, immunocompromised: single dose of immune globulin

Invasive meningococcal Not vaccinated: begin antimicrobial chemoprophylaxis asap (no more than 14 days of exposure)
infection
*droplets

Pertussis Should be vaccinated every 10 years
*droplets

Tetanus Uncertain/Incomplete history of primary 3-dose series: tetanus toxoid-containing vaccine (Td, Tdap, TT)
Clean wounds → if most recent alrd >10 yrs: tetanus toxoid-containing vaccine (Td, Tdap, TT)
Dirty wounds → if most recent alrd >5 yrs: tetanus toxoid-containing vaccine (Td, Tdap, TT)
*add immune globulin if it is unclear the primary 3-dose series has been completed (except for clean wounds)

Tuberculosis Tuberculin skin test or IFN-y release assay within 8-12 weeks of exposure
*airborne If positive → treat w/ Isoniazid + vitamin B6 for 9 months

Diphtheria Any close contacts regardless of immunization status: Either Td or Tdap if no documentation of 3-dose primary series + one dose of drug

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