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Summary Draft of Research Investigation.docx PSY 300 Draft of Research Investigation Southern New Hampshire University PSY 300: Biopsychology Autism spectrum disorder (ASD) is a developmental disorder that affects communication and behavior. According to t $7.49   Add to cart

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Summary Draft of Research Investigation.docx PSY 300 Draft of Research Investigation Southern New Hampshire University PSY 300: Biopsychology Autism spectrum disorder (ASD) is a developmental disorder that affects communication and behavior. According to t

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Draft of Research I PSY 300 Draft of Research Investigation Southern New Hampshire University PSY 300: Biopsychology Autism spectrum disorder (ASD) is a developmental disorder that affects communication and behavior. According to the Diagnostic and Statistical Manual of Mental Disorders (DSM...

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  • June 13, 2021
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PSY 300
Draft of Research Investigation



Southern New Hampshire University


PSY 300: Biopsychology



Autism spectrum disorder (ASD) is a developmental disorder that affects communication

and behavior. According to the Diagnostic and Statistical Manual of Mental Disorders (DSM-5)

(2013), individuals that are diagnosed with autism spectrum disorder have difficulty

communicating and interacting with other individuals, restrictive and/or repetitive patterns of

behavior or interests, and symptoms that cause significant impairments in social, occupational, or

other areas of life. According to the Centers for Disease Control and Prevention (CDC) (2020),

based on data from a survey conducted in 2016 about 1 in 54 children were diagnosed with

autism spectrum disorder and it is more than 4 times more common among boys than girls.

Literature Review


Cochran et al. (2015) proposed that there is an imbalance of excitatory and inhibitory

neurotransmission in autism spectrum disorder. They compared glutamate (Glu), glutamine

(Gln), and y-aminobutyric acid (GABA) levels in the anterior cingulate cortex (ACC) of 13

males diagnosed with ASD and 14 typically developed (TD) males who were between the

ages of 13-17 years and they correlated the levels with intelligence quotient (IQ) as well as

measures of social cognition. The researchers acquired the neuroimaging data using a 3.0 Tesla

Philips Achieva whole-body MR system with an eight-element phased-array head coil at the

Advanced MRI Center at the University of Massachusetts Medical School (UMMS). A

neuroradiologist who was board certified at UMMS read the anatomic MRI scans and no

abnormalities were identified (Cochran et al., 2015). The results of the study show that there

, were higher Gln levels and lower GABA/Cre levels in the ASD group than in the TD group and

there was no difference in Glu levels between the groups.

DeMayo et al. (2019) claim that the amygdala has an important role in social

development, most likely as a gatekeeper that coordinates and integrates processing between

other critical circuits for attention, sensory integration, motor coordination, and reward. They

propose that the amygdala plays a crucial role for facilitating the ability to engage and learn from

social experiences within the caregiver-infant dyad. The authors state that there is evidence to

suggest the pathways that regulate the Activation, Integration, Discrimination, Response, and

Reward (AIDRR) are primarily coordinated by the amygdala, particularly the basolateral

amygdala (BLA). This is based on functional and structural connectivity findings linking it to

the superior temporal sulcus (STS).

Hotier et al. (2017) found that the ascending ramus of the superior temporal sulcus (STS)

is longer in children with ASD that are high functioning compared to typically developing

children, with a more pronounced difference in the right hemisphere. However, they claim that

the morphology of the structures has not been examined in adults with ASD and that it is

unknown whether the morphology of the posterior superior temporal sulcus (pSTS) branches can

mediate social cognition abilities in healthy people or in individuals with ASD. The authors

hypothesized that the length of the anterior caudal branch of the superior temporal sulcus would

be longer among patients with ASD and the length would be associated with the measures of

social cognition. They state that the superior temporal sulcus is one of the key components of the

“social brain” and it plays a central role in social cognition, which includes the processing of

face perception and Theory of Mind. Theory of Mind is the ability to assign mental states to

others and use them to predict the behavior of others and is processed within the posterior area of

the STS.

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