100% satisfaction guarantee Immediately available after payment Both online and in PDF No strings attached
logo-home
Samenvatting klinische biologie D1-3 $17.54   Add to cart

Summary

Samenvatting klinische biologie D1-3

 30 views  3 purchases
  • Course
  • Institution

Samenvatting van deel 1 tot 3: Algemene inleiding, Koolhydraten, Lipiden H1-11

Preview 4 out of 47  pages

  • June 15, 2021
  • 47
  • 2020/2021
  • Summary
avatar-seller
Deel 1: Algemene inleiding in de klinische biologie
Hoofdstuk 1: Inleiding

1. Definities

- Metabolisme = verzameling v. chem reacties i/e levend organisme met doel het org.
gezond te houden

o Katabolisme: afbraak v. macromoleculen tot bouwstenen & verbranding
ervan -> E genereren
o Anabolisme: bouwstenen w. aaneengeschakeld tot macromoleculen -> E
vereist

è Onderverdeling: metabole paden
o Aaneenschakeling v. chem. reacties met begin- & eindpunt
o Katalyse dr. enzymen

è 2 centrale gegevens:
o Genereren v. voldoende E vr. levensfuncties
o Verzamelen v. bouwstoffen om versleten mol. te vervangen of nieuwe aan te
maken

2. Metabole paden en flux

- Signaalwegen lopen stapsgewijs

o Intermediairen: prod. gevormd bij omzetting v.
begin- nr. eindpunt
o Structuur:
§ Evolutionair bewaard (bij mens & andere levensvormen)
§ Soms slechts i/h deel v/d levende natuur

Metabole flux:
= omloopsnelheid v. mol. dr. een metabool pad

- Foute regeling kan leiden tot ziekte/dysfunctie
- 3 doelen:
1) Leveren v. E (ATP)
2) Leveren v. BS
3) Leveren v. reducerend vermogen (gereduceerd NADPH (zet CO2 om in
glucose))

- ATP: adenosine trifosfaat
- NADPH: nicotinamide adenine dinucleotide fosfaat




1

,3. Katabole en anabole wegen

Katabolisme:

- Chem. E & reducerend vermogen onttrekken aan omgeving
dr. opname & oxidatie v. brandstoffen
- Bv.: oxidatieve fofolysering

- Doel: cellen voorzien v. chem. E

- Fasen:
Fase 1: Glycogenolyse
Fase 2: Beta-oxidatie v. lipiden, glycolyse, aminozuur-afbraak & oxidatieve
decarbolyxering
Fase 3: Krebcyclus
è Volledige verbranding v. acetyl-CoA tot CO2




Anabolisme:

- Mol. produceren nodig vr. het in stand houden, groei & voortplanting v. organismen
- Vereisen ATP & NADPH
- Bv.: synthese v. basen

- Doel: synthese v. nieuwe mol., vertrekkende v. BS

- Vereisten:
o BS : sommigen opgenomen via voeding ->
essentiële voedingsstoffen
o Andere: ATP & NADPH




2

,Thermodynamica:
= studie v/ E, omzetting v. E tss versch. vormen & het vermogen v. E om arbeid te leveren

- 3de wet thermodynamica:

∆G = ∆H – T . ∆S

∆G: (verandering van) vrije energie van Gibbs
∆H: (verandering in) enthalpie
T: absolute temp.
– T . ∆S: (verandering in) entropie x T° (K)


- Entropie (S)
= mate v. wanorde
o ∆S > 0 -> wanorde
o ∆ < 0 -> orde


10J warmte w. opgenomen dr.
koffie -> ruimte verliest 10J warmte




10J warmte w. afgestaan a/d ruimte
-> koffie verliest 10J




- Enthalpie (H)
= verandering in warmte-E wnr. Reagentia w. omgezet
o H > 0 -> endotherme rea.
o H < 0 -> exotherme rea.




3

, - Vrije E v. Gibbs (∆G)
= voorspelt richting v/d rea.
o ∆G > 0 -> endergonische rea. (niet spontaan)
o ∆G < 0 -> exergonische rea. (spontaan)




- Transitietoestand: hoogst energetische toestand
v/h E diagram
- Activeringsenergie (Ea): E versch. tss. begin- &
transitietoestand




è Enzymen houden
alles onder controle

è Enzym bindt aan
katalysator ->
activerings-E daalt




4

The benefits of buying summaries with Stuvia:

Guaranteed quality through customer reviews

Guaranteed quality through customer reviews

Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.

Quick and easy check-out

Quick and easy check-out

You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.

Focus on what matters

Focus on what matters

Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!

Frequently asked questions

What do I get when I buy this document?

You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.

Satisfaction guarantee: how does it work?

Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.

Who am I buying these notes from?

Stuvia is a marketplace, so you are not buying this document from us, but from seller StudentEhbLL. Stuvia facilitates payment to the seller.

Will I be stuck with a subscription?

No, you only buy these notes for $17.54. You're not tied to anything after your purchase.

Can Stuvia be trusted?

4.6 stars on Google & Trustpilot (+1000 reviews)

78998 documents were sold in the last 30 days

Founded in 2010, the go-to place to buy study notes for 14 years now

Start selling
$17.54  3x  sold
  • (0)
  Add to cart