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Class notes Central Carbon Metabolism: Physiology Of Microorganisms Brock Biology of Microorganisms plus Pearson Mastering Microbiology with Pearson eText, Global Edition, ISBN: 9781292235226 $4.82
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Class notes

Class notes Central Carbon Metabolism: Physiology Of Microorganisms Brock Biology of Microorganisms plus Pearson Mastering Microbiology with Pearson eText, Global Edition, ISBN: 9781292235226
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  • Course
  • Physiology Of Microorganisms
  • Institution
  • Radboud Universiteit Nijmegen (RU)
  • Book
  • Brock Biology of Microorganisms plus Pearson Mastering Microbiology with Pearson eText, Global Edition

This document includes the central carbon metabolism based on the lecture

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Document information

  • June 16, 2021
  • 4
  • 2020/2021
  • Class notes
  • Hanna koch
  • Central carbon metabolism

Subjects

  • carbon metabolism
  • central carbon metabolism
  • microbiology
  • citric acid cycle
  • physiology of microorganisms

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  • Radboud Universiteit Nijmegen (RU)
  • Bachelor Biology
  • Physiology Of Microorganisms
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L4 – CENTRAL SUGAR METABOLISM
GLYCOLYSIS (GLUCOSE + 2 ADP + 2 NAD + → 2 PYRUVATE + 2 ATP + 2 NADH + + 2 H + )

Two stages in glycolysis:

- Energy investment stage
- Pay off stage

1. ENERGY INVESTMENT STAGE (2 ATP INVESTED)




2 moles of ATP are invested at steps Hexokinase and Phosphofructokinase

1. Glucose is irreversibly phosphorylated by hexokinase, 1 ATP is invested
2. Glucose-6-P is converted into Fructose-6-P by isomerase
3. Fructose-6-P is irreversibly phosphorylated by phosphofructokinase, 1 ATP invested
4. Fructose-1,6-bisphosphate is reversibly converted into Dihydroxyacetone-P and
Gylceraldehyde-3-P by aldolase
- Phosphofructokinase is subjected to allosteric regulation
o Lower activity due to high ATP levels
o Important control point for glycolysis
o If there are a lot of ATPs present, no need for glycolysis

2. PAY OFF STAGE (1 GLUCOSE → 4 ATP & 2 NADH)

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