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Organophosphate Poisoning - OP Poisoning
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Organophosphate Poisoning - OP Poisoning Causes Physiological basis Treatment
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For the insects only!!June 11, 2020
Pesticides are chemicals that are used to kill pests such as
bacteria, insects, snails, rats and so on. ... Insecticides are
a type of pesticide that is used to specifically target and kill
insects.
Organophosphates are the major components present in
most insecticides. It acts by inhibiting
acetylcholinesterase, the enzyme that breaks down
acetylcholine. As excess acetylcholine is not cleared up
from the site of release and action, there
is overstimulation of the acetylcholine receptors. This
leads to excess action of the acetylcholine molecule
eventually leading to cholinergic crisis.
, Nerve agents used in chemical warfare contain a more
potent and toxic form of Organophosphates.
Acetylcholine is a neurotransmitter released from
parasympathetic nerve endings. The actions of
acetylcholine depends on their site of action and receptors.
The acetylcholine receptors are classified as Nicotinic and
Muscarinic receptors.
The Nicotinic receptors are named so because the
stimulation of these receptors by acetylcholine leads to
effects similar to actions of nicotine.
Muscarine is a toxin present in a specific type of poisonous
mushrooms known as toadstools. The muscarinic
receptors are named so because, in smooth muscles and
glands, the stimulation of these receptors by muscarine
leads to effects similar to stimulation by acetylcholine.
Acetylcholine is the chief neurotransmitter released from
parasympathetic nerve endings. Once released, it binds to
specific receptors on the target organs. Upon binding, it
stimulates the receptors leading to the receptor and
location specific actions of acetylcholine.
Acetylcholinesterase(AChE) is the molecule that helps
break down acetylcholine(ACh), thus preventing
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