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samenvatting farmacologie immunologie
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volledige samenvatting van farmacologie immunologie
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Immunotherapie eigen afweersysteem stimuleren de tumorcellen op te ruimen
Kan niet voor alle tumoren
Andere vorm van ‘toxiciteit’: andere bijwerkingen!
1. Cytokinen (Interferonen, interleukine-2):
Signaalmoleculen bij ontstekings- en afweerreacties
Toedienen van cytokinen = aspecifiek versterken van afweersysteem
Bijwerkingen:
- grieperig gevoel en koorts
- spierpijn, hoofdpijn, verminderde eetlust
- vermoeidheid
- beenmergsuppressie
2. Monoklonale antilichamen: “checkpoint remmers”
Immuun checkpoints = beveiliging in het afweersysteem om afweerreacties uit
te schakelen wanneer deze op gezonde cellen gericht zijn
(auto-immuunreacties voorkomen)
Tumoren ‘kapen’ deze checkpoints om afweercellen te deactiveren
Checkpointremmers schakelen dit beveiligingssysteem uit zodat de tumor
opnieuw ‘zichtbaar’ wordt voor het afweersysteem
Andere vorm van toxiciteit: rem op afweersysteem wordt weggehaald
DUS Kans op auto-immuunreacties!
- huiduitslag
- darmontsteking met diarree
- longontsteking
- vermoeidheid
- hormonale stoornissen
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