Summary
Samenvatting farmacologie: Antihormonale behandeling
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Samenvatting farmacologie: Antihormonale behandeling
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Antihormonale behandelingprincipe
• heel wat tumoren afhankelijk van hormonen voor groei, differentiatie en metastasering
hormoonafhankelijke tumoren
bv. borstkanker, endometriumkanker, prostaatkanker
• opheffen van groeistimulerende werking van natuurlijke hormonen (oestrogeen,
progesteron, testosteron) reductie tumor
• Chirurgisch verwijderen hormoonproducerende organen, bv. eierstokken
• Synthetische anti-hormonen:
- werking van de betrokken hormonen blokkeren (receptoren blokkeren)
- aanmaak van de betrokken hormonen blokkeren
antagonisme tussen chemotherapie en anti-hormonale therapie! (werken elkaar tegen)
Synthetische anti-hormonen
• werking van de betrokken hormonen blokkeren (receptoren blokkeren)
- Anti-oestrogenen (tegen oestrogenen)
- Anti-androgenen (tegen mannelijk hormoon)
• aanmaak van de betrokken hormonen blokkeren
- Aromatase-inhibitoren (remmen enzyme aromatase)
- GnRH-producten
Anti-oestrogenen
Indicatie: hormoongevoelig borstcarcinoom
Werking:
blokkeren van oestrogeenreceptoren
Soorten:
- Selectieve oestrogeen receptor modulatoren (SERM: selectief op borstweefsel)
- Volledige antagonisten (alle oestrogeenreceptoren in lichaam)
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