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Lecture 4 Metabolism- Glycolysis notes
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This is a document which clarifies the lecture content into an easier format to understand. As the metabolism topic is one of the hardest to follow.
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Lecture 9¥Glycolysis
-
Active Recall Questions :
1 Where ?
.
is
glycolysis located
cells
cytosol of
eukaryotic
-
2 What is
.
glycolysis ?
Glucose converted to
pyruvate
3 What 2 of
. are the main sections
glycolysis ?
STAGE I into cell
getting
-
↳ trap t destabilise glucose =
produces 2 ✗ 3C
↳ requires 2 ATP 's molecules
per glucose
STAGE 2 breakdown to
get energy
-
↳ oxidation of 3C molecules to
pyruvate
↳
generates
4 ATPÉ & 2 NADA per glucose molecule
4 . What are the 3 main transporters for
glucose uptake &
their functions ?
GLUT 2 -
liver , B- cells , pancreas ( uptake ✗ extracellular glucose conc.
)
GLUT 3 -
Brain , nerve tissue ( constant uptake)
GLUT 4 muscles ( uptake INSULIN]
adipocytes controlled
by
-
,
↳ no . of GLUT 4 can be ipicreased via exercise
, Glycolysis -10 steps
④ Trap glucose in cell via
phosphorylation
Hexo kinase
Glucose + ATP → Glucose 6- phosphate + ADP + Itt
(G- Gop)
G- GP
negative charge Ican't freely diffuse)
has
-
-
Phosphate group starts glucose de stabilisation
-
Catalyst : muscle = hexokinase
liver =
glucokinase
② Fructose 6- phosphate formation
-
Enzyme used :
phospho glucose isomerase
-
reversible reaction
-
Isomerization reaction ( glucose to fructose]
OH H H
CHYY-H.PH
O H
pH
"
c - d d d d
- - - -
CHZOPO ;
-
2- c - d -
c -
c -
CHZOPO > 2-
' ' ' "
¥
/ ' "
H OH H OH OH OH ¥
Glucose 6- phosphate Fructose 6- phosphate
③ /kE4REaUATor=T
.an,.µ.µ, , µ
Phosphorylation of Fructose 6- phosphate STEP
-
Enzyme used :
Phospho fructokindse Allosteric regulation
via tetramer
INHIBITED BY :
☐
ATP a
citrate o Ht
Fructose 6- phosphate + ATP → Fructose 1,6 -
+ ADP + Ht
STIMULATED BY :
g.m.mn,
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