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Presentation Pharmaceutical Formulation (PHCO2310)
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- Institution
A presentation of manufacturing and physical tests. Highlights the tests required to assess the quality of immediate and sustained release tablets.
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TABLET MANUFACTURINGAND PHYSICAL TEST
PHCO231
AYOMIDE GBOLAG
P2574
,INTRODUCTION
• The aim of this study was to perform a series of tests on the tablets to determine the suitability of the tablets for safe
consumer and commercial use.
• The tests carried out were a mix of British Pharmacopeia (BP) and non-BP tests. The BP tests carried out were the Uniformity
of Weight, Disintegration Test, Crushing Weight, Uniformity of Tablet Diameter, Uniformity of Tablet Thickness and Friability
test.
• The non-BP tests are also known as additional tests. These tests are important to test the compaction force used during
tableting and compression to ensure the tablet is adequately robust.
• The two types of tablets used for this study are immediate release (IR) which has a compression force of 12,400 N and
sustained release (SR) which has a compression force of 10,800 N. These tablets were manufactured under direct
compression
• The direct compression manufacturing mechanism involves mixing an API with a disintegrant, dry binder and direct
compression base (standard diluent) together and compressing them into tablets.
• An immediate release tablet is formulated to be released without delay to the target site whereas a Sustained release tablet
is formulated to be released in the bloodstream over a period of time
, PURPOSE OF STUDY
• The purpose of this study is to determine if the quality of tablets comply with BP standards.
• The BP is a book that is regulated by the British Pharmacopeia Commission. It contains legal standards
that present the quality to which medicinal products in the UK must meet.
• This is important for the safeguarding of the health of those who use medicinal products in the UK.
• This study allows us to form an understanding of why these individual pharmacopeial tests are
necessary in determining of the tablet's suitability for commercial use.
• This study also allows us draw conclusions from the results about the properties of the tablets and
evaluate changes that could be made to the formulations.
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