Summary
BBS2062 (Allometry), a complete and clear summary
- Course
- Institution
A complete and clear summary including pbl cases and lectures
[Show more]
Seller
Follow
MasterstudentUM
Reviews received
Content preview
22/06/2021Course BBS2061 Allometry
Pluis, CMH
22/06/2021 Pluis, CMH 1
Lecture 1
Pluis, CMH
22/06/2021 Pluis, CMH 2
1
, 22/06/2021
Lecture 1 - Opening
• What is the relevance of Allometry for Biomedical Sciences?
• Extrapolation from mouse to human
• Assessment of / correction for influence of body size in human studies
• Size range in biomedical research
• Patients: scale is between newborns and adults
• Biomedical research: scale is between mouse and human
• Biological research: scale is between smallest animal (C. Elegans Drosophila) and largest
animal (horse)
22/06/2021 Pluis, CMH 3
Lecture 1 - Opening
• Genetic principles are studies in mice.
• Then, translation research in, for instance, a goat (large animals correspond more
with humans than small animals such as mice).
• Then, clinical practice in humans.
22/06/2021 Pluis, CMH 4
2
, 22/06/2021
The exponential form is y = ax^b, as you say and the logarithmic form
is log(y) = log(a) + b*log(x). It's the same formula, just written
Lecture 2 differently using the rules for logarithms, and so the meaning of b also
doesn't change. However, the interpretation that b>1 means positive
allometry and b<1 means negative allometry is only valid when you
compare like dimensions (e.g. length to length, area to area). As you
Pluis, CMH can see in the examples in the opening lecture, when you are
comparing a surface area to a volume (or body mass), you would
expect b = 2/3 for isometry, b < 2/3 for negative allometry and b > 2/3
for positive allometry. For many relations (e.g. longevity vs. body
mass), it is not possible to define when a relation would be isometric...
22/06/2021 Pluis, CMH 5
Lecture 2 – Introduction to Allometry
• Allometry describes how the characteristics of leaving creatures change with size
• Old definition:
• Allometry describes the scaling relationship between the size of a body part and the size of
the body as whole, as both grow during development
• Recently, its definition has changed
• Allometry describes the biological scaling relationships in general
• An increase in size may require a change in design
• For example: bridge or locomotion in swimming animals
22/06/2021 Pluis, CMH 6
3
, 22/06/2021
Lecture 2 – Introduction to Allometry
• Because differences in gender, age and body
mass may affect the outcome measure,
there is correction for body size in clinical
practice
• For example in renal function and pulmonary
function
• Example: ear
• Large animals are sensitive for lower frequencies
• For example, elephant: transmissions of low-
frequency waves via ground which are detected
by feet
• Small animals are sensitive for higher
frequencies
22/06/2021 Pluis, CMH 7
Lecture 2 – Introduction to Allometry
• History of Allometry
• Leonardo Da Vinci
• Throughout his life, da Vinci studied anatomy
• Differences in ganglion cells between species
22/06/2021 Pluis, CMH 8
4
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller MasterstudentUM. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $6.85. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
65507 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy study notes for 15 years now