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Summary

Acute coronary syndrome summary

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Summary of acute coronary syndromes including STEMI, NSTEMI and unstable angina. Notes on symptoms, investigations and management.

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  • September 13, 2021
  • 4
  • 2019/2020
  • Summary
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ACS

Suspect ACS when: chest pain more than 15 minutes, N+V, sweating, breathlessness, haemodynamic
instability, pain occurs without exertion. DO NOT use response to GTN to confirm or exclude diagnosis.
Normal ECG does not exclude ACS.

Initial management

 M: morphine (+IV metoclopramide/cyclizine)
 O: oxygen if sats below 94%
 N: GTN
 A: aspirin 300 mg then 75 mg OD
 C: clopidogrel 300 mg then 75 mg OD
 All ACS can be given PCI if haemodynamically unstable

Plus, start: secondary prevention atorvastatin 80 mg ON, beta blocker bisoprolol 2.5 mg OD, LMWH
fondaparinux (can also start ACEI)

Long term management

 Beta blocker for 12 months – reduces myocardial demand
 ACEI – prevents cardiac remodelling
 GTN spray PRN
 Aspirin (lifelong), clopidogrel (12 months), statin
 BP control, lifestyle modifications (Mediterranean diet, exercise, smoking cessation)

Symptoms

 Central crushing chest pain
 Occurs several times a day with increasing severity
 Can occur at rest (unstable angina)
 Radiation to jaw, arm or neck
 Dyspnoea and tachycardia
 Nausea and sweating

Unstable angina

NO ST elevation on ECG with negative cardiac markers

 Risk factors: female, older age > 50, family history, personal history of CAD, hypertension, diabetes,
hyperlipidaemia, obesity, smoking
 Differentials
o Stable angina – pain occurs only by exertion and is relieved by GTN or rest
o STEMI – ECG ST elevation
o NSTEMI – raised cardiac markers
 Diagnostic investigation is CT coronary angiography

NSTEMI

Acute ischaemic event. NO ST elevation on ECG with positive cardiac markers. Men and women present
differently. Men typical chest pain lasting several minutes. Women middle/upper back pain with dyspnoea.

 Risk factors: increasing age, previous CAD, smoking, diabetes, obesity, dyslipidaemia
 Investigations
o ECG
o Cardiac biomarkers

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