Class notes PHARMACOLOGY (BASICS) Essentials of Medical Pharmacology, ISBN: 9789352704996
21 views 0 purchase
Course
PHARMACOLOGY (BASICS)
Institution
Bachelor Of Pharmacy
Book
Essentials of Medical Pharmacology
This notes are important for the students are preparing for the competitive exams after pharmacy. Basics and Classification of drugs are describes by simple words.
Kindly refer this notes and review me to improve.
, Introduction
• First time suggested by Sir Henry Dale
• Wide distribution
• Adrenergic neurons are also present in CNS
(hypothalamus and reticular formation)
• Three endogenous catecholamines
(Catechol nucleus + an amine)
Eg. Adrenaline (Epi), Nor-adrenaline
(NE), Dopamine (DA)
• Isoprenaline is not endogenously present (Benzene ring with
2 adjacent OH groups)
in the body
, Noradrenergic transmission
• Adrenaline: It is secreted by adrenal medulla
and also have transmitter role in the brain
• Nor-adrenaline: Act as NT at post ganglionic
sympathetic sites
• Dopamine: Major NT in basal ganglia, limbic
system, CTZ, anterior pituitory etc.
• Isoprenaline: Synthetic derivative of NA; not
found in the body
, History of NA
• Oliver and Schaffer (1895) first reported that injection of
extracts of adrenal glands in cat increases BP
• Takamine (1901) purified active principle of adrenal
gland and named it as ADRENALINE
• Henry Dale (1906) observed in anesthetized cat that the
rise in BP by iv injections of ADR could be changed to
fall in BP on pre-treatment with ERGOT.
“VASOMOTOR REVERSAL OF DALE”
• This experiment showed that ADR caused two distinct
effects i.e. vasoconstriction and vasodilatation. This effect
give rise to the concept of different sets of receptors for
Adrenergic NS.
• Ergot blocked vasoconstrictor effect (α1) without
interfering with vasodilatation effect (β2)
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller PrasadKolapkar. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $7.49. You're not tied to anything after your purchase.
