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Class notes PHARMACOLOGY Essentials of Medical Pharmacology, ISBN: 9789352704996
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This document covers the basics regarding adverse drug reaction and pharmacovigilance. Refer and review.
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ADVERSE DRUGREACTIONS
(Pharmacovigilence)
,Adverse (Drug) Reaction
(ADR)
,From the earliest times,
pharmaceutical formulations have
been recognized as being potentially
dangerous.
Indeed it is a truism that unless a
drug is capable of doing some
harm it is unlikely to do much
good.
Public and professional concern
about these matters first arose in the
late 19th century.
In 1922, there was an enquiry into
the JAUNDICE associated with the
use of SALVARSAN, an organic 3
arsenical used in the treatment of
, In 1937 in the USA, 107 people died
from taking an ELIXIR OF
SULFANILAMIDE that contained the
SOLVENT DIETHYLENE GLYCOL
This led to the establishment of the
FOOD AND DRUG
ADMINISTRATION (FDA), which was
given the task of enquiring into the
safety of new drugs before allowing
them to be marketed.
Major modern catastrophe that
changed professional and public
opinion towards medicines was the
THALIDOMIDE INCIDENT.
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