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Samenvatting OW4 farmacologie specifieke medicatie
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Dit is een uitgebreide samenvatting van OW4 farmacologie specifieke medicatie.
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Specifieke medicatieCoronaire ziekten
1. Lipide verlagende geneesmiddelen
Cholesterol is een lipide verkregen uit dierlijke vetten, maar word ook
gesynthetiseerd in de lever.
stabiliteit van celmembranen
grondstof voor steroïdhormonen en vitamine D
2 soorten:
HDL
o haalt cholesterol uit weefsels naar lever
LDL
o vervoer van cholesterol uit lever naar weefsels
onevenwicht HDL-LDL: cholesterol in weefsels-> plaques
-
Statines remmen enzymen HMG-CoA reductase. Dit enzym leidt tot de
aanmaak van cholesterol in de lever.
Voorbeelden Geneesmiddelen:
Statines
Atorvastatine
Simvastatine
, Statines met een korte halfwaardetijd kunnen het best ´s avonds gebruikt
worden, omdat de lever vooral ´s nachts cholesterol aanmaakt.
2. Anticoagulantia
Anticoagulantia kan inwerken op:
Thrombocytenaggregatie
Samenklonteren van bloedplaatjes
o Clopidogrel
o Acetylsalicylzuur
Asaflow/aspirine
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