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Ontwikkeling van leukemie
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Ontwikkeling van leukemie
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Ontwikkeling van leukemie- Specifieke categorie van kanker
- Leukemie (‘wit bloed’)
- Bloedbuisje van leukemiepatiënt: onderin rode bloedcellen, bovenin klein beetje
plasma en heel erg veel witte bloedcellen (normaal ong 1%).
Namen kanker:
- Neoplasma (tumor): abnormale massa van weefsel
o Opgebouwd uit één normale lichaamscel die heel veel is gedeeld
(monoclonaal)
o Benigne of maligne
- Maligne: kunnen in weefsel groeien (met schade) of kunnen uitzaaiingen veroorzaken
- Kanker: maligne neoplasma
- Maligne transformatie = cellulaire verandering
Neoplasma wordt benoemd door:
- Origine cel
- Benigne of maligne
Leukemie Colorectaal carcinoom
(dikke darm kanker)
Plaats van ‘herkomst’ Beenmerg Darm
Type initiërende cel Stamcellen Stamcellen
Aantal initiërende cellen 1 1
Normale groei regulatie van Groeifactoren Groeifactoren
initiërende cellen door:
Differentiatie van (Witte) bloedcellen Cellen die slijm produceren
initiërende cel (enterocyten)
Hoeveel typen >40 1
Niveau van differentiatie Hangt van type af Variabel
Acute > weinig
gedifferentieerd (lijken op
stamcel)
Initiërende schade van DNA DNA
(DNA, RNA, eiwit)
Type van initiërende Translocatie Puntmutaties/deleties etc
genetische schade
Pathway van betrokken Groei Groei
genen
Premaligne stadium Ja, myelodysplasie Ja, adenomen
(neoplasma dat nog niet is
uitgezaaid)
Is screening relevant? Nee Ja
Hoe lang duurt het voordat Jaren Jaren
symptomen verschijnen na
eerste genetische ‘event’?
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