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Samenvatting Mechanism of blood coagulation - Bloedstolling $3.25   Add to cart

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Samenvatting Mechanism of blood coagulation - Bloedstolling

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Bloedstolling - Mechanism of blood coagulation

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  • October 1, 2021
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  • 2016/2017
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MECHANISM OF BLOOD
COAGULATION - BLOEDSTOLLING
GENERAL MECHANISM

Na propvorming; bloedstolling: stollingsfactoren worden in een proces
geactiveerd (coagulatie)
1. Cascade (proces dat in stappen verloopt) van chemische reacties in het
bloed waarbij heel veel bloed coagulatie factoren bij betrokken zijn:
complex van geactiveerde stoffen ontstaat: protrombineactivator
2. Protrombineactivator > protrombine in bloedplasma wordt omgevormd tot
actief trombine
3. Trombine katalyseert de vorming van fibrinedraden uit fibrinogeen:
fibrinedraden dichten de vaatbeschadiging: verstrikken bloedplaatjes,
bloedcellen en plasma
Procoagulantia: stoffen die bloedstolling stimuleren
Anticoagulantia: stoffen die bloedstolling tegengaan
Stolling van het bloed; hangt af van balans tussen deze factoren > normaal: de
balans helt over naar anticoagulantia zodat het bloed vloeibaar wordt gehouden
CONVERSION OF PROTHROMBIN TO THROMBIN

Protrombineactivator
wordt gevormd doordat een
bloedvat gescheurd is of
doordat speciale stoffen in
het bloed beschadigd zijn.

De protrombineactivator in
de aanwezigheid van
genoeg Ca²⁺ > omzetting van
protrombine in trombine

Trombine zorgt ervoor dat
fibrinogen moleculen
polymeriseren in
fibrinedraden




PROTHROMBIN AND THROMBIN

Protrombine wordt gevormd door de lever. De lever heeft vitamine K nodig om
protrombine normaal te activeren. Als de lever te weinig vitamine K heeft of de
lever functioneert niet goed > vermindert protrombine aanmaak >
bloedingsneiging

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