Summary

Samenvatting Geneesmiddel overzicht algemen farmacotherapie

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Course
Algemene Farmacotherapie (WMFA00811)

Institution
Rijksuniversiteit Groningen (RuG)

Geneesmiddeloverzicht met de belangrijkste bijwerkingen, interacties, contra-indicaties + relevante informatie over behandelrichtlijnen. Gebruik voor mondeling is zeer geschikt en volledig.

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Uploaded on October 25, 2021
Number of pages 86
Written in 2020/2021
Type Summary

algemen farmacotherapie
farmacotherapie
eerstelijns therapie

Institution
Rijksuniversiteit Groningen (RuG)
Education
Farmacie
Course
Algemene Farmacotherapie (WMFA00811)

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Medicatieoverzicht
Algemene farmacotherapie

Inhoud
Medicatieoverzicht.................................................................................................................................0
Algemeen...........................................................................................................................................2
Labwaardes.....................................................................................................................................2
Hart- en vaatziektes............................................................................................................................3
Werkingsmechanismen..................................................................................................................3
Hartfalen.........................................................................................................................................5
Hypertensie....................................................................................................................................7
Angina pectoris...............................................................................................................................9
Atriumfibrilleren...........................................................................................................................12
Antitrombotica.............................................................................................................................13
Maag-darmklachten.........................................................................................................................15
Werkingsmechanismen................................................................................................................15
Maag.............................................................................................................................................19
Anti-emetica.................................................................................................................................21
Obstipatie/diarree........................................................................................................................22
Inflammatoire darmaandoeningen...............................................................................................24
PDS (prikkelbare darmsyndroom).................................................................................................26
Obesitas........................................................................................................................................27
Anticonceptie en overgang...............................................................................................................28
Werkingsmechanismen................................................................................................................28
Anticonceptie................................................................................................................................29
Vaginaal bloedverlies/uitstel menstruatie....................................................................................32
Zwangerschap...............................................................................................................................32
Overgang......................................................................................................................................32
Pijn....................................................................................................................................................34
Werkingsmechanismen................................................................................................................34
Pijnladder.....................................................................................................................................36
Aandachtspunten opiaten............................................................................................................38
Migraine.......................................................................................................................................39
Neuropathische pijn.....................................................................................................................40
Jicht..............................................................................................................................................41

, Reuma..........................................................................................................................................41
Overige klachten bewegingsapparaat...........................................................................................43
Infecties............................................................................................................................................43
Werkingsmechanismen................................................................................................................43
Spectra antibiotica........................................................................................................................44
Algemene bijwerkingen................................................................................................................45
Behandelingen..............................................................................................................................45
Antimycotica.................................................................................................................................48
SOA...............................................................................................................................................49
Huid, oog, oor...................................................................................................................................50
Werkingsmechanismen................................................................................................................50
Indeling dermatocorticosteroïden................................................................................................52
Medicatie huidaandoeningen.......................................................................................................52
Behandeling eczeem.....................................................................................................................55
Behandeling psoriasis...................................................................................................................56
Medicatie oogaandoeningen........................................................................................................57
Medicatie ooraandoeningen........................................................................................................58
Luchtwegen......................................................................................................................................59
Werkingsmechanismen................................................................................................................59
Hoesten........................................................................................................................................60
Astma............................................................................................................................................61
COPD.............................................................................................................................................61
Medicatie astma/COPD................................................................................................................62
Neurologie........................................................................................................................................63
Werkingsmechanismen................................................................................................................63
Epilepsie.......................................................................................................................................65
Anti-parkinson medicatie + rusteloze benen................................................................................66
Multiple Sclerose (MS)..................................................................................................................68
Delirium........................................................................................................................................69
Dementie......................................................................................................................................69
Aangrijpingspunten receptoren....................................................................................................70
Slaapstoornissen...........................................................................................................................70
Benzodiazepinen..........................................................................................................................72
Anxiolytica/anti-panica.................................................................................................................72
Tabak/alcohol...............................................................................................................................73
Anti-depressiva.............................................................................................................................73

1

, Antipsychotica..............................................................................................................................75
Endocrien..........................................................................................................................................77
Werkingsmechanismen................................................................................................................77
Diabetes mellitus..........................................................................................................................79
Osteoporose.................................................................................................................................81
Urologie........................................................................................................................................83
Schildklier.....................................................................................................................................84

Algemeen
Labwaardes
Parameter Streefwaardes
SBD < 140 mm Hg onder de 70 jaar
140 mm Hg boven de 70 jaar
150 mm Hg bij kwetsbare ouderen -> te laag ortostatse en vallen
LDL <2,6 mmol/l boven de 70 jaar
< 1,8 mmol/l bij risicofactoren
Kreatinine < 200 micromol/l
Kalium 3,5 – 5 mmol/l
Natrium 135 – 145 mmol/l

2

, BNP <100 pg/ml
Ejectie <40%
eGFR Bij ouderen (70 jaar) ongeveer 30
INR 2-4
Urinezuur en jicht >0,35 mmol/l

Hart- en vaatziektes
Werkingsmechanismen
Medicatie Werkingsmechanisme
Hartfalen, hypertensie, coronair
Koolzuuranhydrase remmers inhiberen NaHCO3 reabsorptie in de proximale tubulus.
Mannitol Veroorzaakt waterdiurese ten hoogte van de proximale tublus en dalende deel lis van Henle.
Het wordt namelijk makkelijker gefiltreerd via de glomeruli en beperkt teruggeresorbeerd.
Daardoor verhindert het de terugresoprtie van water en verhoogt de uitscheiding van
elektrolyten. Het effect is geforceerde diureese.
- Grote hoeveelheden vocht wordt dan uitgescheiden, het is alleen minder
gecontroleerd. In chronische situaties is dit minder wenselijk
Lisdiuretica Inhiberen selectief de Na+/K+/2Cl- carrier bij het opstijgende deel van de lus van Henle.
- Furosemide Remmen daarmee het passieve transport van natriumionen. De toniciteit van de medulla
- Bumetanide wordt minder en daarmee het vermogen om urine te concentreren. Het bevordert

3

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