COMPLETE TEST BANK: Fundamentals of Molecular Virology 2nd Edition by Nicholas H. Acheson Latest Version.
Test Bank for Fundamentals of Molecular Virology 2nd edition by Acheson, ISBN: 9780470900598, All 37 Chapters Covered | Complete Solution Guide.
Fundamentals of Molecular Virology 2nd edition by Acheson - Test Bank, All 37 Chapters Covered, Verified Latest Edition
All for this textbook (13)
Written for
The University of Kent (UKC)
The University of Kent
BI606 Pathogens And Pathogenicity
All documents for this subject (2)
Seller
Follow
zalan
Content preview
HIV Replication Cycle (Early Phase)
HIV Life Cycle:
Early Phase
1. Attachment & entry
2. Reverse transcription & synthesis of DNA
3. DNA integration into host genome
Late Phase
1. RNA transcription
2. HIV polypeptides
3. Virion assembly & exit
3. DNA Integration into Host Genome
The excised 3’ nucleotides create a 5’ overhang on each side
* Additionally integrase nicks the host genome at a random position, generating staggered
2-bp ends
HIV ‘DNA’ inserts into the nicked sites in the host genome by ligation
Viral 5’ ends are removed and the gaps are repaired by host repair mechanisms
The overall process generates integrated viral genome called a provirus
Provirus includes 2 copies of the U3-R-U5 region termed the long terminal repeat (LTR)
1. Integrase clips 2 nucleotides off both 3’ ends of viral cDNA = the
excised 3’ nucleotides create a 5’ overhang on each side.
o integrase nicks the host genome at a random position,
generating staggered 2-bp ends
2. HIV ‘DNA’ inserts into the nicked sites in the host genome by ligation.
3. Viral 5’ ends are removed and the gaps are repaired by host repair
mechanisms.
=Generates an integrated viral genome = provirus
Provirus includes 2 copies of the U3-R-U5 region = long terminal repeat (LTR).
When cells are not replicating, HIV can remain in nucleus in non-integrated cDNA form.
Integrase action only occurs in replicating cells (to enable integration of viral cDNA)
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller zalan. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $7.09. You're not tied to anything after your purchase.