100% satisfaction guarantee Immediately available after payment Both online and in PDF No strings attached
logo-home
Previously searched by you
Previously searched by you
logo
Samenvatting Fysiopathologie en ziekteleer (Behaald Resultaat: 16/20): diabetes $7.01   Add to cart
Quickly navigate to
Preview
  2.  
  3. Universiteit Antwerpen (UA)
  4.  
  5. Biomedische Wetenschappen
  6.  
  7. Fysiopathologie En Ziekteleer

Summary

Samenvatting Fysiopathologie en ziekteleer (Behaald Resultaat: 16/20): diabetes
 4 views  0 purchase
  • Course
  • Fysiopathologie En Ziekteleer
  • Institution
  • Universiteit Antwerpen (UA)

Dit document bevat alles van wat je moet kennen over diabetes: Alles van wat er in de les gezegd is door de prof staat als notitie bij de slide geschreven. Leer dit en je bent er zeker door (Behaald Resultaat: 16/20).

Preview 4 out of 45  pages

Document information

  • November 5, 2021
  • 45
  • 2021/2022
  • Summary

Subjects

  • 3e ba bmw
  • bmw
  • biomedische wetenschappen
  • atero
  • atherosclerose
  • diabetes
  • longen
  • hart
  • nieren
  • hartfalen
  • fysiopatho
  • 2021 2022
  • 2020 2021
  • 2019 2020
  • examenvragen
  • fysiopathologie e
  • fysiopathologie en ziekteleer

Written for

  • Universiteit Antwerpen (UA)
  • Biomedische Wetenschappen
  • Fysiopathologie En Ziekteleer
All documents for this subject (72)

Seller

avatar-seller
lemmeslodders

Reviews received

Content preview

Diabetes Mellitus
acute en chronische verwikkelingen


Prof. dr. C. De Block,
Prof. dr. L. Van Gaal
november 2008




chronische complicaties: prevalentie

MICROVASCULAR MACROVASCULAR

Retinopathy,
Cerebrovascular
glaucoma or
disease
cataracts

Coronary
Nephropathy heart
disease


Peripheral
Neuropathy vascular
disease




50% type 2 diabetici vertonen reeds complicaties bij diagnose

UK Prospective Diabetes Study Group. UKPDS 33. Lancet 1998; 352:837–853.




1

, chronische complicaties: prevalentie


• frequentste oorzaak van blindheid bij volwassen
• frequentste oorzaak van nierinsufficiëntie (> 1/3 van
dialysepat.)





• 2-4 x meer sterfte door ischemisch hartlijden
• 2-6 x meer cerebrovasculaire accidenten
• 4 x meer perifeer vaatlijden
• 15 x meer lidmaatamputaties (> 65 j x 25)

• kosten : 7-15 % van uitgaven voor gezondheidszorg




Chronische complicaties: pathogenese
risicofactoren
• hyperglycemie
– multiple pathways
• hypertensie
• hyperlipidemie
• overgewicht
• roken
• sedentaire levensstijl

• genetica
• duur DM
• leeftijd




2

, Chronische complicaties: pathogenese
Mechanismen waarbij hyperglycemie-geïnduceerde mitochondriale superoxide
overproductie de 4 pathways van hyperglycemie-schade activeert




Brownlee, Diabetes 2005




chronische complicaties: pathogenese
The polyol (sorbitol) pathway




Aldose reductase reduceert glucose tot sorbitol. Sorbitol dehydrogenase (SDH) oxideert
sorbitol tot fructose.
In cellen waar voldoende aldose reductase activiteit is om gereduceerd glutathione (GSH) te
depleteren wordt de oxidative stress verhoogd.
Brownlee, Diabetes 2005




3

, chronische complicaties: pathogenese
hexosamine pathway




oiv de hexosamine pathway stijgt
de productie van PAI-1 and TGF-β




Brownlee, Diabetes 2005




chronische complicaties: pathogenese
protein kinase C pathway




4

The benefits of buying summaries with Stuvia:

Guaranteed quality through customer reviews

Guaranteed quality through customer reviews

Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.

Quick and easy check-out

Quick and easy check-out

You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.

Focus on what matters

Focus on what matters

Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!

Frequently asked questions

What do I get when I buy this document?

You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.

Satisfaction guarantee: how does it work?

Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.

Who am I buying these notes from?

Stuvia is a marketplace, so you are not buying this document from us, but from seller lemmeslodders. Stuvia facilitates payment to the seller.

Will I be stuck with a subscription?

No, you only buy these notes for $7.01. You're not tied to anything after your purchase.

Can Stuvia be trusted?

4.6 stars on Google & Trustpilot (+1000 reviews)

67474 documents were sold in the last 30 days

Founded in 2010, the go-to place to buy study notes for 14 years now

Start selling
$7.01
  • (0)
  Add to cart