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Samenvatting Fysiopathologie en ziekteleer (Behaald Resultaat: 16/20): diabetes $6.97
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Samenvatting Fysiopathologie en ziekteleer (Behaald Resultaat: 16/20): diabetes
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  • Course
  • Fysiopathologie En Ziekteleer
  • Institution
  • Universiteit Antwerpen (UA)

Dit document bevat alles van wat je moet kennen over diabetes: Alles van wat er in de les gezegd is door de prof staat als notitie bij de slide geschreven. Leer dit en je bent er zeker door (Behaald Resultaat: 16/20).

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Document information

  • November 5, 2021
  • 45
  • 2021/2022
  • Summary

Subjects

  • 3e ba bmw
  • bmw
  • biomedische wetenschappen
  • atero
  • atherosclerose
  • diabetes
  • longen
  • hart
  • nieren
  • hartfalen
  • fysiopatho
  • 2021 2022
  • 2020 2021
  • 2019 2020
  • examenvragen
  • fysiopathologie e
  • fysiopathologie en ziekteleer

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  • Universiteit Antwerpen (UA)
  • Biomedische Wetenschappen
  • Fysiopathologie En Ziekteleer
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Diabetes Mellitus
acute en chronische verwikkelingen


Prof. dr. C. De Block,
Prof. dr. L. Van Gaal
november 2008




chronische complicaties: prevalentie

MICROVASCULAR MACROVASCULAR

Retinopathy,
Cerebrovascular
glaucoma or
disease
cataracts

Coronary
Nephropathy heart
disease


Peripheral
Neuropathy vascular
disease




50% type 2 diabetici vertonen reeds complicaties bij diagnose

UK Prospective Diabetes Study Group. UKPDS 33. Lancet 1998; 352:837–853.




1

, chronische complicaties: prevalentie


• frequentste oorzaak van blindheid bij volwassen
• frequentste oorzaak van nierinsufficiëntie (> 1/3 van
dialysepat.)





• 2-4 x meer sterfte door ischemisch hartlijden
• 2-6 x meer cerebrovasculaire accidenten
• 4 x meer perifeer vaatlijden
• 15 x meer lidmaatamputaties (> 65 j x 25)

• kosten : 7-15 % van uitgaven voor gezondheidszorg




Chronische complicaties: pathogenese
risicofactoren
• hyperglycemie
– multiple pathways
• hypertensie
• hyperlipidemie
• overgewicht
• roken
• sedentaire levensstijl

• genetica
• duur DM
• leeftijd




2

, Chronische complicaties: pathogenese
Mechanismen waarbij hyperglycemie-geïnduceerde mitochondriale superoxide
overproductie de 4 pathways van hyperglycemie-schade activeert




Brownlee, Diabetes 2005




chronische complicaties: pathogenese
The polyol (sorbitol) pathway




Aldose reductase reduceert glucose tot sorbitol. Sorbitol dehydrogenase (SDH) oxideert
sorbitol tot fructose.
In cellen waar voldoende aldose reductase activiteit is om gereduceerd glutathione (GSH) te
depleteren wordt de oxidative stress verhoogd.
Brownlee, Diabetes 2005




3

, chronische complicaties: pathogenese
hexosamine pathway




oiv de hexosamine pathway stijgt
de productie van PAI-1 and TGF-β




Brownlee, Diabetes 2005




chronische complicaties: pathogenese
protein kinase C pathway




4

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