Summary
Samenvatting Protein Structure and Dynamics NL
- Course
- Institution
- Book
De samenvatting is gebaseerd op de hoorcolleges aangevuld met de literatuur.
[Show more]
Connected book
Book Title:
Author(s):
- Edition:
- ISBN:
- Edition:
More summaries for
-
Essential Cell Biology 5th Edition by Alberts
-
Essential Cell Biology 5th Edition by Alberts
-
COMPLETE TEST BANK: ESSENTIAL CELL BIOLOGY 5TH EDITION ALBERTS [ CONTAIN ANSWER KEY Questions with 100% correct Answer.
Seller
Follow
tesskilian
Content preview
Maandag 9 september 2019Protein Structure & Dynamics
Lill, H
2.1 Amino Acids
- The general structural properties of amino acids
- Chirality of amino acids
- The chemical classes of amino acids, their determining features, and which amino
acids belongs to which class
Structuur is bepalend voor functie.
Aminozuren
- Aminegroep (belangrijk in de oplossing)
- Zuurgroep (carboxylgroep, belangrijk in de oplossing)
- aC-atoom (centraal)
- Zijketen (bepaalt de chemische eigenschappen van het aminozuur)
Zwitter-ion: zowel positieve als negatieve ladingen (fysiologisch pH)
Chiraal koolstofatoom: 4 verschillende groepen
Klassen: onderscheiding in zijketen!
- Negatief geladen aminozuren: zijketen met carboxylgroep: COO-
- Positief geladen aminozuren: zijketen met aminegroep: NH 2 kan proton opnemen >
NH3+)
- Niet geladen (wel polaire) aminozuren: zijketen met hydroxyl groep -OH
- Hydrofobe (niet polaire) aminozuren: zijketen zit alleen C en H
2.2 Protein structure
- How amino acids polymerize to build peptides
- The four niveaus of protein structure and their characterizing features
- What motifs and domains are
Prionen: eiwitten die hun structuur kwijtraken, worden meestal afgebroken op opgeruimd in
het lichaam. Bij prionen worden gezonde eiwitten ook ‘besmet’ met de verkeerde structuur
> celdood.
Voobeeld: Alzheimer’s, Kanker (eiwit: P53), Cystis fibrosis.
P53 checkt de eiwitten in ons lichaam. Fout > ruimt foute cel op. Als P53 zelf muteert, doet
die het niet meer. De controle is uitgeschakeld. De mutatie zelf leidt niet voor kanker, maar
wel als de controleur gemuteerd wordt.
- Primaire structuur: sequentie van aminozuren die een polypeptide (macromolecuul)
vormen. Aminozuren zijn verbonden door peptidebindingen (condensatiereactie), er
1
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller tesskilian. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $5.36. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
54879 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy study notes for 14 years now