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Samenvatting Het Hexavalente vaccin

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Dit document omschrijft alle onderdelen van het hexavalente vaccin: Tetanus, difterie, kinkhoest, hepatitis B, Haemophilus influenzae B, polio. Per onderdeel wordt de transmissie, inhaalvaccinatie, kliniek, epidemie, risicogroepen, samenstelling ... besproken

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  • January 3, 2022
  • 7
  • 2021/2022
  • Summary
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Hexavalent vaccin
Elise Bamps




Difterie, tetanus, kinkhoest, polio, hepatitis B, Haemophilus Influenzae B

, HEXAVALENT VACCIN
DTPa-IPV-Hib-HepB (hexacym/ hexyon) (hoofdletters: pediatrisch)  8W, 12W, 16W, 15M, 5-7jr (haemophilus en hepatitis niet), 14-16jr (enkel difterie,
tetanus, kinkhoest)

- Difterie (kroep)
- Tentanus (klem)
- Kinkhoest (Bordatella pertussis)
- Polio
- Hepatitis B(geelzucht)
- Haemphilus influenza B (hersenvliestontsteking)

vergelijken met mastermind: iets toevoegen en zien wat het geeft, heel veel kwaliteitsstappen, productie kost 20M, stel no go: opnieuw beginnen
tetanus DIFTERIE kinkhoest Haemophilus influenza Hepatitis B poliomyelitis
type B
Wat? -anaerobe gram + kiem Cornyebacterium Bordatella pertusis 6 gekapselde subtypes: <hepadnaviridae =enterovirus
-kiem en sporen wijd diphteriae B veroorzaakt meest DNA virus 3 serotypes (I, II, III)
verspreid Aeorobe gram – invasieve infecties 4 major genes:
Toxine gemedieerd  Aerobe gram + - S (surface) Targets motor-neurons  1/200
tetanospasmine (via -toxine gemedieerd - C(core) ademhalings paralyse
Hoge mortaliteit
bloed/ lymfe) => -incubatietijd: 2-5d - P (polymerase) =>ijzeren long
-toxine gemeedieerd
spiercontracties, spasmen - X (transactivating)
(werken paralyserend
zonder relaxatie (3-4W
op cilai en veroorzaken >99% asymptomatisch
aanwezig) =>Anti-ABS antisgoffen
inflammatie => slijmen)
VB. spasmen masseter => tegen HbsAg
Inubatietijd: 4-21d
rara lach: risus sardonicus
Ingangspoort: wonde

Inhaal >10jr na rappel/ Immuniteit na infecite: Kind 6jr: vluchteling Moeilijkheid: enorm veel
vaccinatie primovaccinatie: niet blijvend, na zonder vaccinaties  vreiwilligers nodig => nationale
1 rappel vaccinatie ook niet vaccinatie niet meer immunisatie dagen: kids <5jr op
>20 jr na rappel/ opstarten: immuniteit een week vaccinteren met
primovaccinatie: Reservoir: mesen voldoende sterk om te druppelvaccin  pinknagel purper
0-6 schema vermiijden dat het kleuren
Geen documenten: invasief wordt Moeilijkheden: religie, politiek,
Inhaalvaccinatie: 0, 1m, unawareness, inaccesibility, lack of

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