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Blood clot formation and lysis
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In-depth summary of the blood clot formation process
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Blood clot formation / lysisMonday, 20 September 2021 5:04 PM
Hemostasis – blood clot formation
- Platelet activation
- Primary hemostatic plug
o Unstable
o Stability is normally provided by blood coagulation cascade
o Enzymes Facilitate the formation of thrombin which facilities formation of
fibrin
§ Strengthening material deposited on plug to trap white / red cells to
form stable plus
- Positive feedback
o Platelet response
o Blood coagulation cascade
Hemostatic response
- Vessel is damaged
o Exposure of endothelial surface
§ Collagen exposed
- Vasoconstriction
o Contraction of smooth muscle
o Reduced blood flow
o Contributes to formation of primary hemostatic plug
- Platelet response
o Adhesion (VWF)
§ Von williebrand factor
§ Result of collagen exposure
§ Adhesion to vessel injury
o Platelet activation
§ Shape change
§ Granule secretion
§ Activation of GPIIb/IIIa
§ Glycoprotein
§ Receptor for VWP and fibrinogen
§ Aids platelet activation
§ Release platelet phospholipid
§ Blood coagulation cascade
§ Discharge of chemical mediators
§ Have a positive feedback on activation of platelets
o Release Serotonin, ADP, thromboxane A2
§ Lead to platelet aggregation
§ Contribute to vasoconstriction
§ Thromboxane A2 has positive feedback effect on activation of platelets
o Formation of Primary platelet plug
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