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Samenvatting Hematologie

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Samenvatting Hematologie, geschreven in 2019/2020

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  • January 6, 2022
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  • 2019/2020
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Hematologie samenvatting hoorcollege 1-8 HU
2019/2020
Les 1: introductie hematologie
Circulatie:

 Waarom circulatie?
o O2 opnamen en afgifte
o Vervoer voedings- en afvalstoffen
 Soorten circulatie:
o Pulmonale circulatie(longen voorzien van O 2)
o Systematische circulatie(toevoer van O2 rijk bloed naar organen)
 2 bijzonderheden:
o PoortADER systeem= O2 rijk bloed naar lever
o Pulmonale circulatie Arterie=O2 arm, Vene=O2 rijk

De structuur van bloedvaten:

 Arterie dikke spierlaag om bloedvat
 Capillair=haarvatenloopt door endotheel, zorgt voor snelle diffusie
 Vene cavavormt zich naar beschikbare ruimte, hebben bloedvaatkleppen tegen terugstroming

Capillair endotheel

 Bloedtoevoer geregeld door sfincters(kringspier+afsluitfunctie)
o Soorten capillair: (doorlatbaarheid=ruimte tussen de cellen)
 Continue capillair veel in brein, lage doorlaatbaarheid
 Gefenestreerde capillair veel rond de darm, middelmatige doorlaatbaarheid
 Sinusoïde capillair veel rond beenmerg, hoge doorlaatbaarheid
 Capilaire wand:
o Hydrostatische druk vocht van bloed naar buiten
o Colloïd osmotische druk neemt vocht op van weefsel
 Samen voorkomen ze vocht ophopingen
o Weefselvocht wordt met behulp van lymfen in de vene gebracht

Bloed componenten

 Bloed valt onder de groep bindweefsel omdat het verantwoordelijk is voor transport.
o Bloed componenten:
 Erytrocyten +/- 5x1012 per L
 Leukocyten +/- 5x109 per L
 Trombocyten +/- 25x109 per L
 Alle 3 worden in beenmerg gemaakt(hematopoëse)

, RBC Indices:

 RBC= Red Bloodcell Count 1/L
 Hb= Hemoglobine concentratie mol/L
 Ht= Hematocriet concentratie L/L
o MCV= Mean Cell Volume Ht/RBC
o MCH= Mean Cell Hemoglobine Hb/RBC
o MCHC= Mean Cell Hemoglobine Concentratie Hb/Ht

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