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Samenvatting hematologische ziekten en stollingsstoornissen: 1e master BMW $4.28   Add to cart

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Samenvatting hematologische ziekten en stollingsstoornissen: 1e master BMW

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goede samenvattingen van alle aandoeningen

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  • January 6, 2022
  • 5
  • 2021/2022
  • Summary
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VERDIEPING IN ZIEKTELEER: HEMATOLOGISCHE ZIEKTEN &
STOLLINGSSTOORNISSEN

HEMATOLOGISCHE ZIEKTEN & STOLLINGSSTOORNISSEN
Hematologie = specialisme dat zich bezig houdt met afwijkingen v/h bloed, de bloedvormende organen en
lymfeklieren

1. Hematologische ziekten
Benigne: goedaardige aandoeningen
Maligne: hemato-oncologische aandoeningen
2. Stoornissen in bloedstolling
Verhoogde bloedingsneiging = bloedingsdiathese
Verhoogde trombosneiging = thrombofilie


HEMATOLOGISCHE ZIEKTEN
3 reeksen:
- Verschuiving richting myeloide reeks = L-verschuiving
- Verschuiving richting NK/ lymfocyten = R- verschuiving

Terminologie:
RBC: Anemie VS polycytemie
WBC: leukocytopenie VS leukocytose
TBX: thrombocytopenie VS thrombocytose

Klinisch:
Tekort
- RBC: bleekheid, vermoeidheid, palpitaties, dyspnee
- WBC: infecties
- BP: bloeding

Teveel met verdenking op maligniteit
- B-symptomen
Voelbare klieren of adenopathieën --> pijnlijk?
Organomegalie, hepatosplenomegalie
Onverklaarde jeuk, icterus

Technische onderzoeken:
- Perifeer veneus bloed
o CBC = compleet --> Concentratie absoluut/ procentueel
o Perifeer bloeduitstrijkje
o Genetisch
- Beenmerg na punctie
- Weefsel naar biopsie

Anticoagulans toevoegen (EDTA)
1. RBC onderaan
2. WBC & BP
3. Bloedplasma + fibrinogeen

, VERDIEPING IN ZIEKTELEER: HEMATOLOGISCHE ZIEKTEN &
STOLLINGSSTOORNISSEN

Spectrum hematologische ziekten




RODE REEKS
RBC
= 4 globineketens + 4 haemgroepen + Fe
--> max 4 O2- stoffen kunnen binden

O2 tekort –> Epo stim beenmerg voor erythropoiese

CASUS 1: ANEMIE
- Melaena = zwarte stoelgang
- Kijken naar conjunctiva --> kleur bekijken
- Fe: belangrijk voor RBC en wondheling --> 2mg nodig uit de voeding

Ferriprieve anemie
- Alle leeftijden
- Mild --> ernstig
- Onderliggend probleem?
- Tekort aan Fe = verhindering synthese & werking Hb
- Tgv chronische bloedverlies

Behandeling:
- Onderliggende oorzaak
- Fe-supplementen
- Ernstige vorm: RBC transfusie

Normo MCV --> nierinsuff OF chronische inflammatie
Macro MCV --> B12 & foliumzuur
Reticulocytose = indicatie v/h tempo waarmee beenmerg RBC aanmaakt

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