Case
Case effect BBS1003 Statistics
- Course
- Institution
Case of 13 pages for the course BBS1003 Statistics at UM (.)
[Show more]
Seller
Follow
summa2023
Content preview
Faculty of Health, Medicine and Life SciencesBBS1003 Syllabus 2020-2021 202020
, Faculty of Health, Medicine and Life Sciences
1.1.1 Seminar 3.2 assignments
Don’t forget watching the videos!
Statistical concepts to be discussed: one sample t-test, paired samples t-test, two or more
independent samples t-test, multiple comparison problem, t-test statistic
You need to memorize the standard error formula only of the one sample and paired sample
estimated value under null hypothesis
t-test. Further T = in all situations
seof estimate
Problem 1 > see SPPS instructions below!
Consider the following sav-file: ‘Colon_SOD_wide.sav’
The superoxide dismutase study (A. Janssen et al. (1998), data modified) concerns the role of
the oxidant-antioxidant balance in the initiation, promotion, and therapy resistance of cancer.
Superoxide dismutase (SOD) is a key antioxidant enzyme, scavenging the superoxide radical
(O2 –), which is a precursor molecule for all other reactive oxygen species and their
derivatives. By scavenging O2 –, SOD form the first line of defence against oxidative stress
and its subsequent effects. In human cells three isoenzymes of SOD exist: cytosolic (Cu,Zn-
SOD; SOD1), mitochondrial (Mn-SOD; SOD2) and extracellular (EC-SOD, SOD3).
Disturbances in the functioning of the SOD isoforms lead to numerous pathological changes
in the human organism, including tumor disease. In order to get more insight into the
relationship between SOD expression and the development of colorectal cancer the SOD
concentration (ng/mg protein) of normal mucosa and carcinoma tissues of colorectal cancer
patients (n=271) was measured and related to several clinicopathological parameters and the
survival time of the patients.
Relevant variables:
pat_number: patient number
msode_normal_mucosa: Mn-SOD in ng per mg protein of normal mucosa
msode_carcinoma: Mn-SOD in ng per mg protein of carcinoma
surviv: survival, coded 0 for survivors, and 1 for non-survivors.
survt: survival time in months
survt_grp: survival time classified into 4 categories, 1= 0.5-10 months; 2=11-57 months; 3=58-
105 months; 4=106-157 months
tnm01: developmental stage of carcinoma, 0= early development stage (TNM1 & 2; 1 advanced
development stage (TNM3 & 4). TNM (Tumor, Node, Metastasis) is an international accepted
staging system for colorectal carcinomas ranking from 1 to 4.
gender01: gender of patient, 0= female; 1=male
a. Perform a one-sample t-test to test whether the average Mn-SOD in carcinoma tissue
at population level is equal to 800 ng/mg protein. Perform the analysis using the
following steps
BBS1003 Syllabus 2020-2021 212121
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller summa2023. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $3.75. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
72042 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy study notes for 14 years now