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Samenvatting tentamenstof FA-BA301 psychofarmacologie
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Volledige samenvatting van tentamenstof voor psychofarmacologie, met plaatjes uit het boek ter illustratie.
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Psychofarmacologiei
FA-BA301
Universiteit Utrecht
2021-2022
JD
, Slaap video khan 's academy
→
4 stages →
90 minuten
NON Rapid
-
Eye Movement
tetris sleep
V1
→
NU →
'
fail →
hypnicjecks
theta Waves
nthmmmmm
→ harder +0 Ware UP
Nz Mmm " hibit
Cognitive
More theta k -
complex
( sleep ' e. 9 '
sleep through load noicè)
gpinaeeg
~ →
gegaan,
gyyyq.mg
delta Waves
Rapid eye Movement ( REM)
→
paradoxaal sleep
musdes parakesed
→
→De 4-5 Cycles minute
→
90
each Cycle N, → Nz → N> →
Nz →
Rem →
Ny
?⃝
, ttypothalamic regulation of sleep and
Circa dian Rhythms
→
paper by Saper
ascending arousal System
originates uit Pons : yellow pathway
→
Upper
n
• TT laterodorsastegmental
: nuclei
•
PPT: pedunculopontine
→
facilitator thatamocortic.ae transmission
.
→
Neurons in PPT / LDT Vuren het snelst
t dens waakzaamheid en Rem slaap
-
. #
"" de" " "" " "
%
→
mi"" " "t " " ""
Red
Pathway → activatie cerebrale cortex to
facilitaire Processing of inputs from thalamus
Arise from :
•
( TMN) tuberomammillary nucleus (Histamine)
•
ATO cells group ( dopamine)
•
Dorsal and mediaan raphe nuclei ( serotonine)
•
(LC) locus Coeruleus ( Noradrenaline)
•
( LHA) latere Hypothalamus ( orexin ,
Melanin Concentration
-
g Hormoon)
(BF) Basat ( GABA Ach)
•
forebrain or
Lesions in LHA and rostra midbrain → coma
ij
, Insomnia -
• ksions in Basat ganglia and anterior hypothalamus
VLPO →
Sends output to ael cell
groups involved in arousal
•
VLPO neuronen Z n Vooral actief t dens slaap → bevatten remmende neurotransmitters GABA
en
guanine
Orexins / hypocretins
•
Only produced b neuronen cluster in posterior Half of LHA
Narcolepsie Vermindering
•
→
van orexin-2 receptor
orexin neurons vooral actief t dens waak
→
→
Versterken Arousal systeem , maar remmen VLPO niet
•
Waarsch nl k ter stabilisatie fkpflop eenvoudig ongewild in
•
van -
systeem
:
niet
slaap Vallen , niet zomaar ontwaken
Homeostase van slaap
accumulatie sleep promoting substantie
-
Adenosine →
eindproduct degradatie ATD ,
lang wakker bl ven leidt tot accumulatie in Basat forebrain .
Toediening van adenosine Veroorzaakt slaap b katten ,
( ircadian regulatie van slaap
Suprachiasmatic nucleus Brains
'
→ Master Cloud
↳ resets onder invloed licht
daily →
van en melatonine uit
de p nappelklier
ijijijij ij ij
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