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Physiology Summary (Biology RUG yr 1) $7.40
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Physiology Summary (Biology RUG yr 1)

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Summaries of the course Physiology of the study Biology at the University of Groningen. The summaries are based on the lectures and are written per subject. Pictures from the lectures and from the internet have been added.

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  • January 12, 2022
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  • 2021/2022
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Physiology notes

Local communication between cells
a. Gap junctions form direct cytoplasmic connections between
adjacent cells.
Single-unit smooth muscle cells are connected by gap junctions, and the cells
contract as a single unit.
b. Contact-dependent signals require interaction between
membrane molecules on 2 cells. A natural killer immune cell recognizes a
healthy cell of the body by binding to a ‘self’ marker on the cell’s surface.
c. Autocrine signals act on the same cell that secreted them.
Paracrine signals are secreted by one cell and diffuse to adjacent
cells.
Long distance communication between cells. Hormones in the endocrine
system are always travelling via the blood. Hormones effect cells with
receptors  response. Hormones are secreted by endocrine glands or
cells into the blood. Only target cells with receptors for the hormone
respond to the signal.
Neurotransmitters and neurohormones in the nervous system.
Neurotransmitters are chemicals secreted by neurons that diffuse
across a small gap to the target cell. Neurohormones are chemicals
released by neurons into the blood for action at distant targets.
Speaking and listening
 Ligands: first messengers
 Bind to receptor proteins  response
 Intracellular processes
o Signal pathways: second messengers
 2 messengers  cellular response
nd

 Behavioural and physiological response

Intracellular (in the cell) and membrane receptors (on the cell)
a. Intracellular signal receptors: lipophilic signal molecules diffuse
through the cell membrane. Binding to cytosolic or nuclear receptor
triggers.
b. Cell membrane receptors: extracellular signal response binds to a
cell membrane receptor  binding triggers  rapid cellular
response.

Intracellular receptors:
Lipid soluble ligands
 Steroid hormones
o Corticosterone/cortisol
o Testosterone
o Oestradiol
o Thyroid hormones
Cell membrane receptors:
Water soluble ligands
 Neurotransmitters
 Lipophobic hormones

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